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Tchem Glutathione S-transferase kappa 1

Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).

This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]

 Comments

Property Summary

Ligand Count 2
NCBI Gene PubMed Count 38
PubMed Score 12.99
PubTator Score 2053.61

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Osteoarthritis 184 0.0 0.0
Prostatic Neoplasms 495 0.0 0.0
Disease Target Count
Degenerative polyarthritis 115

Expression

  Differential Expression (7)

Disease log2 FC p
glioblastoma 1.600 2.4e-04
malignant mesothelioma -1.300 2.0e-06
Multiple myeloma 1.100 8.6e-04
osteosarcoma -1.570 1.2e-04
ovarian cancer 2.200 7.9e-07
subependymal giant cell astrocytoma 1.454 1.7e-02
tuberculosis 1.600 1.0e-09

Synonym

Accession Q9Y2Q3 B4DIH1 B4DSY2 Q6P4H0 Q7Z520 Q9P1S4
Symbols GST
GST13
hGSTK1
GSTK1-1
GST13-13
GST 13-13

Gene

GSTK1

  Ortholog (12)

Species Source Disease
OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (7)

 GO Function (4)

 GO Component (6)

 GO Process (3)

 Compartment GO Term (22)

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 MGI Phenotype (7)

 HCA RNA Cell Line (56)

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Pathway (13)

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Protein-protein Interaction (5)

HSPD1   PAG1   LIMA1   PPP2R2D   TK2  

PDB (3)

Drug (1)

Structure of glutathione

glutathione
pIC50 7.70

Ligand (1)

Structure of CHEMBL1543

CHEMBL1543
pIC50 7.70

Gene RIF (18)

AA Sequence 

MGPLPRTVELFYDVLSPYSWLGFEILCRYQNIWNINLQLRPSLITGIMKDSGNKPPGLLPRKGLYMANDL      1 - 70
KLLRHHLQIPIHFPKDFLSVMLEKGSLSAMRFLTAVNLEHPEMLEKASRELWMRVWSRNEDITEPQSILA     71 - 140
AAEKAGMSAEQAQGLLEKIATPKVKNQLKETTEAACRYGAFGLPITVAHVDGQTHMLFGSDRMELLAHLL    141 - 210
GEKWMGPIPPAVNARL                                                          211 - 226
//

Text Mined References (44)

PMID Year Title