| Tchem | Glutathione S-transferase kappa 1 |
Significant glutathione conjugating activity is found only with the model substrate, 1-chloro-2,4-dinitrobenzene (CDNB).
This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
This gene encodes a member of the kappa class of the glutathione transferase superfamily of enzymes that function in cellular detoxification. The encoded protein is localized to the peroxisome and catalyzes the conjugation of glutathione to a wide range of hydrophobic substates facilitating the removal of these compounds from cells. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Osteoarthritis | 184 | 0.0 | 0.0 |
| Prostatic Neoplasms | 495 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Degenerative polyarthritis | 115 |
| Disease | Target Count | P-value |
|---|---|---|
| tuberculosis | 2010 | 1.0e-09 |
| ovarian cancer | 8520 | 7.9e-07 |
| malignant mesothelioma | 3232 | 2.0e-06 |
| osteosarcoma | 7950 | 1.2e-04 |
| glioblastoma | 5792 | 2.4e-04 |
| Multiple myeloma | 1332 | 8.6e-04 |
| subependymal giant cell astrocytoma | 2287 | 1.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| glioblastoma | 1.600 | 2.4e-04 |
| malignant mesothelioma | -1.300 | 2.0e-06 |
| Multiple myeloma | 1.100 | 8.6e-04 |
| osteosarcoma | -1.570 | 1.2e-04 |
| ovarian cancer | 2.200 | 7.9e-07 |
| subependymal giant cell astrocytoma | 1.454 | 1.7e-02 |
| tuberculosis | 1.600 | 1.0e-09 |
