Property Summary

NCBI Gene PubMed Count 21
PubMed Score 27.18
PubTator Score 41.79

Knowledge Summary


No data available



Accession Q16772 O43468 Q068V6 Q8WWA8 Q9H415
Symbols GTA3



1TDI   2VCV  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (12)

25248748 analysis of how isomerization of the steroid Delta(5)-androstene-3,17-dione by the glutathione transferase A3-3
24739064 Density functional theory calculations used to propose a refined mechanism for the isomerization of delta(5)-androstene-3,17-dione catalyzed by GST A3-3
23650189 Data indicate that steroidogenic factor 1 (SF-1) and glutathione S-transferase A (GSTA) family genes (hGSTA1-hGSTA4) are involved in steroidogenesis.
20237496 Observational study of gene-disease association. (HuGE Navigator)
20200426 Observational study of gene-disease association. (HuGE Navigator)
20083122 The 3D structures of human GSTs A2-2 and A3-3 in complex with Delta(4)-androstene-3-17-dione, were solved.
19343046 Observational study of gene-disease association. (HuGE Navigator)
18977241 Observational study of gene-disease association. (HuGE Navigator)
18426392 Significantly contributes to the double-bond isomerization necessary for steroid hormone biosynthesis in complex systems, thereby complementing the indispensable 3beta-hydroxysteroid oxidoreductase activity of 3beta-hydroxysteroid dehydrogenase.
17601350 Observational study of gene-disease association. (HuGE Navigator)
15595823 Analysis of the active centers of hGSTA3-3 reveals that residues in positions 12 and 208 may contribute to its disparate isomerase activity toward Delta(5)-AD.
15454730 describe an I71L polymorphism in GSTA3 that occurs at a low frequency in African populations

AA Sequence

KALEEARKIFRF                                                              211 - 222

Text Mined References (21)

PMID Year Title
25248748 2014 The isomerization of ?5-androstene-3,17-dione by the human glutathione transferase A3-3 proceeds via a conjugated heteroannular diene intermediate.
24739064 2014 Isomerization of ?5-androstene-3,17-dione into ?4-androstene-3,17-dione catalyzed by human glutathione transferase A3-3: a computational study identifies a dual role for glutathione.
23650189 2013 Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis.
23533145 2013 In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
20200426 2010 Glutathione pathway genetic polymorphisms and lung cancer survival after platinum-based chemotherapy.
20083122 2010 Structural basis for featuring of steroid isomerase activity in alpha class glutathione transferases.
19343046 2009 Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects.
18977241 2008 Oxidative stress, telomere length and biomarkers of physical aging in a cohort aged 79 years from the 1932 Scottish Mental Survey.
18426392 2008 Targeting human glutathione transferase A3-3 attenuates progesterone production in human steroidogenic cells.
17601350 2007 A genetic association analysis of cognitive ability and cognitive ageing using 325 markers for 109 genes associated with oxidative stress or cognition.
16876319 2006 Mutation analyses of genes on 6p12-p11 in patients with juvenile myoclonic epilepsy.
15595823 2004 Crystal structure of human glutathione S-transferase A3-3 and mechanistic implications for its high steroid isomerase activity.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15454730 2004 Functional polymorphism of human glutathione transferase A3: effects on xenobiotic metabolism and steroid biosynthesis.
14574404 2003 The DNA sequence and analysis of human chromosome 6.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11872752 2002 Active-site residues governing high steroid isomerase activity in human glutathione transferase A3-3.
11418619 2001 Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones.
9480897 1998 Identification of cDNAs encoding two human alpha class glutathione transferases (GSTA3 and GSTA4) and the heterologous expression of GSTA4-4.
8307579 1993 Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes.