Property Summary

NCBI Gene PubMed Count 12
PubMed Score 13.41
PubTator Score 4.99

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
ovarian cancer 8491 1.4e-06
tuberculosis 1563 2.8e-06
pituitary cancer 1972 1.1e-05
psoriasis 6685 1.7e-04
osteosarcoma 7933 1.8e-04
cutaneous lupus erythematosus 1056 6.6e-03

Expression

  Differential Expression (6)

Disease log2 FC p
cutaneous lupus erythematosus 1.300 6.6e-03
psoriasis 1.400 1.7e-04
osteosarcoma -1.041 1.8e-04
tuberculosis 1.100 2.8e-06
ovarian cancer 1.400 1.4e-06
pituitary cancer -1.300 1.1e-05

Gene RIF (4)

PMID Text
27383986 GSDMD N-terminal cleavage product oligomerizes in membranes to form pores that are visible by electron microscopy
26611636 Gene deletion of GSDMD demonstrated that GSDMD is required for pyroptosis and for the secretion but not proteolytic maturation of IL-1beta in both canonical and non-canonical inflammasome responses.
26375003 caspase-1 and caspase-4/5/11 specifically cleaved the linker between the amino-terminal gasdermin-N and carboxy-terminal gasdermin-C domains in GSDMD, which was required and sufficient for pyroptosis
19051310 Study investigated the expression pattern of the GSDM family genes in the upper gastrointestinal epithelium and cancers.

AA Sequence

MGSAFERVVRRVVQELDHGGEFIPVTSLQSSTGFQPYCLVVRKPSSSWFWKPRYKCVNLSIKDILEPDAA      1 - 70
EPDVQRGRSFHFYDAMDGQIQGSVELAAPGQAKIAGGAAVSDSSSTSMNVYSLSVDPNTWQTLLHERHLR     71 - 140
QPEHKVLQQLRSRGDNVYVVTEVLQTQKEVEVTRTHKREGSGRFSLPGATCLQGEGQGHLSQKKTVTIPS    141 - 210
GSTLAFRVAQLVIDSDLDVLLFPDKKQRTFQPPATGHKRSTSEGAWPQLPSGLSMMRCLHNFLTDGVPAE    211 - 280
GAFTEDFQGLRAEVETISKELELLDRELCQLLLEGLEGVLRDQLALRALEEALEQGQSLGPVEPLDGPAG    281 - 350
AVLECLVLSSGMLVPELAIPVVYLLGALTMLSETQHKLLAEALESQTLLGPLELVGSLLEQSAPWQERST    351 - 420
MSLPPGLLGNSWGEGAPAWVLLDECGLELGEDTPHVCWEPQAQGRMCALYASLALLSGLSQEPH          421 - 484
//

Text Mined References (21)

PMID Year Title
27418190 2016 GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death.
27383986 2016 Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores.
27281216 2016 Pore-forming activity and structural autoinhibition of the gasdermin family.
26611636 2015 Gasdermin D is an executor of pyroptosis and required for interleukin-1? secretion.
26375259 2015 Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.
26375003 2015 Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death.
25944712 2015 N-terminome analysis of the human mitochondrial proteome.
25416956 2014 A proteome-scale map of the human interactome network.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21269460 2011 Initial characterization of the human central proteome.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19051310 2009 Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
17350798 2007 Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.
16421571 2006 DNA sequence and analysis of human chromosome 8.
15592455 2005 Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15289881 2004 Identification and characterization of human DFNA5L, mouse Dfna5l, and rat Dfna5l genes in silico.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.