Protein Summary
May promote pyroptosis (Probable). Upon cleavage in vitro of genetically engineered GSDMA, the released N-terminal moiety binds to some types of lipids, such as possibly phosphatidylinositol (4,5)-bisphosphate. Homooligomerizes within the membrane and forms pores of 10 -15 nanometers (nm) of inner diameter, triggering cell death. Also binds to bacterial and mitochondrial lipids, including cardiolipin, and exhibits bactericidal activity (PubMed:27281216). The physiological relevance of these observations is unknown (Probable).
- ENST00000301659
- ENSP00000301659
- ENSG00000167914
- ENST00000635792
- ENSP00000490739
- GSDM
- GSDM1
- GSDM
- FKSG9
- GSDM1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
cell line | 0.59 | ||
phenotype | 0.58 | ||
tissue | 0.5 | ||
disease | 0.47 | ||
gene perturbation | 0.46 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 133.23 (req: < 5)
Gene RIFs: 17 (req: <= 3)
Antibodies: 98 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 133.23 (req: >= 5)
Gene RIFs: 17 (req: > 3)
Antibodies: 98 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 5
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0