Property Summary

NCBI Gene PubMed Count 10
PubMed Score 17.38
PubTator Score 20.41

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (21)

Disease log2 FC p
Waldenstrons macroglobulinemia 1.240 9.4e-03
malignant mesothelioma -5.400 9.5e-10
psoriasis -1.200 3.1e-05
glioblastoma 2.000 4.8e-04
osteosarcoma -1.521 3.1e-02
medulloblastoma -2.300 1.1e-04
cystic fibrosis 2.234 1.2e-06
atypical teratoid / rhabdoid tumor -2.500 6.0e-06
medulloblastoma, large-cell -2.400 5.6e-04
non-small cell lung cancer -2.193 8.6e-19
intraductal papillary-mucinous adenoma (... 1.700 1.5e-03
intraductal papillary-mucinous carcinoma... 1.600 6.8e-03
intraductal papillary-mucinous neoplasm ... 2.100 3.8e-03
lung cancer -3.700 2.6e-06
subependymal giant cell astrocytoma 2.801 8.1e-03
Breast cancer 1.200 4.9e-03
invasive ductal carcinoma 1.236 4.8e-03
Pick disease -1.800 8.2e-06
progressive supranuclear palsy -1.500 1.9e-02
ulcerative colitis 1.900 1.8e-05
ovarian cancer -3.000 4.7e-08

Synonym

Accession A4D1B5 A4D1B6 Q3MJC0 Q8ND73 Q9UMH3 Q9Y4L9 GSAP
Symbols PION

Gene

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (6)

PMID Text
26076991 GSAP cleavage via caspase-3 is regulated and depend upon the availability of 5-Lipoxygenase in Alzheimer's disease.
25037285 Its promoter variant contributes to Alzheimer's disease liability.
23209290 gamma-secretase activating protein (GSAP) and imatinib have roles in the regulation of gamma-secretase activity and amyloid-beta generation
22681044 Protocols for recombinant bacterial expression and purification of potentially important protein GSAP are not successful in generating soluble forms of GSAP that contain well-ordered and homogeneous tertiary structure.
21718343 Aberrant regulation of gamma-secretase activating protein expression plays a key role in acceleration of gamma-cleavage of beta-secretase-cleaved C-terminal fragment of amyloid precursor protein and accumulation of Abeta in AD brains
20811458 A gamma-secretase activating protein (GSAP) that selectively increases amyloid-beta production via interactions with both gamma-secretase and its substrate, the amyloid precursor protein carboxy-terminal fragment.

AA Sequence

MALRLVADFDLGKDVLPWLRAQRAVSEASGAGSGGADVLENDYESLHVLNVERNGNIIYTYKDDKGNVVF      1 - 70
GLYDCQTRQNELLYTFEKDLQVFSCSVNSERTLLAASLVQSTKEGKRNELQPGSKCLTLLVEIHPVNNVK     71 - 140
VLKAVDSYIWVQFLYPHIESHPLPENHLLLISEEKYIEQFRIHVAQEDGNRVVIKNSGHLPRDRIAEDFV    141 - 210
WAQWDMSEQRLYYIDLKKSRSILKCIQFYADESYNLMFEVPLDISLSNSGFKLVNFGCDYHQYRDKFSKH    211 - 280
LTLCVFTNHTGSLCVCYSPKCASWGQITYSVFYIHKGHSKTFTTSLENVGSHMTKGITFLNLDYYVAVYL    281 - 350
PGHFFHLLNVQHPDLICHNLFLTGNNEMIDMLPHCPLQSLSGSLVLDCCSGKLYRALLSQSSLLQLLQNT    351 - 420
CLDCEKMAALHCALYCGQGAQFLEAQIIQWISENVSACHSFDLIQEFIIASSYWSVYSETSNMDKLLPHS    421 - 490
SVLTWNTEIPGITLVTEDIALPLMKVLSFKGYWEKLNSNLEYVKYAKPHFHYNNSVVRREWHNLISEEKT    491 - 560
GKRRSAAYVRNILDNAVKVISNLEARNLGPRLTPLLQEEDSHQRLLMGLMVSELKDHFLRHLQGVEKKKI    561 - 630
EQMVLDYISKLLDLICHIVETNWRKHNLHSWVLHFNSRGSAAEFAVFHIMTRILEATNSLFLPLPPGFHT    631 - 700
LHTILGVQCLPLHNLLHCIDSGVLLLTETAVIRLMKDLDNTEKNEKLKFSIIVRLPPLIGQKICRLWDHP    701 - 770
MSSNIISRNHVTRLLQNYKKQPRNSMINKSSFSVEFLPLNYFIEILTDIESSNQALYPFEGHDNVDAEFV    771 - 840
EEAALKHTAMLLGL                                                            841 - 854
//

Text Mined References (13)

PMID Year Title
26076991 2015 Regulation of gamma-secretase activating protein by the 5Lipoxygenase: in vitro and in vivo evidence.
25037285 2014 Common GSAP promoter variant contributes to Alzheimer's disease liability.
23209290 2013 The role of ?-secretase activating protein (GSAP) and imatinib in the regulation of ?-secretase activity and amyloid-? generation.
22681044 2012 Purification and characterization of the human ?-secretase activating protein.
21718343 2012 Immunohistochemical characterization of ?-secretase activating protein expression in Alzheimer's disease brains.
20811458 2010 Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
16341674 2005 Transcriptome analysis of human gastric cancer.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12853948 2003 The DNA sequence of human chromosome 7.
12690205 2003 Human chromosome 7: DNA sequence and biology.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.