Property Summary

NCBI Gene PubMed Count 38
PubMed Score 574.88
PubTator Score 35.42

Knowledge Summary

Patent (42,401)

Expression

  Differential Expression (6)

Disease log2 FC p
posterior fossa group A ependymoma -1.300 1.4e-10
glioblastoma -1.600 5.3e-07
atypical teratoid / rhabdoid tumor -1.500 1.2e-05
primitive neuroectodermal tumor -1.200 3.0e-03
pediatric high grade glioma -1.300 2.5e-07
pilocytic astrocytoma -1.300 2.7e-07

Protein-protein Interaction (184)

GNAT3   GRM8   F2RL2   P2RY10   CCL21   CXCL11   NPFF   GRM6   CCL25   CCL16   MLNR   HCRT   HCRTR1   HCRTR2   CXCL13   S1PR2   UTS2   NTSR2   S1PR4   F2   OXT   AVP   PENK   PDYN   PPY   NPY   PPBP   PF4   CXCL10   APP   NMB   NPS   SAA1   ADORA3   PYY   CXCL8   MLN   CCL5   ADRA2C   CXCL2   CXCL3   TAC1   PMCH   TRH   TACR2   TBXA2R   TACR1   PTAFR   ACKR3   F2R   NPY1R   HTR2C   NMBR   TACR3   OXTR   SSTR1   SSTR2   NTSR1   NTS   SSTR4   CXCR5   SSTR3   TRHR   PTGER1   SSTR5   OPRM1   AVPR1A   OPRD1   OPRK1   OPRL1   P2RY2   GRM5   CCR2   CXCL5   PTGFR   PTGER3   LPAR6   P2RY1   AVPR1B   XCL1   MTNR1A   CXCL12   NMU   PIK3CG   NPY2R   MTNR1B   CXCR3   NPY4R   P2RY4   CCR9   F2RL1   CCL23   PROK1   TAS2R38   TAS2R39   TAS2R40   TAS2R41   TAS2R43   TAS2R31   TAS2R45   TAS2R46   TAS2R30   TAS2R19   TAS2R20   TAS2R50   TAS2R60   GNG2   CXCR4   SST   CCL20   CXCL6   QRFP   PLCB2   PLCB3   CXCL9   PNOC   GRM7   GRM3   GRM4   P2RY6   P2RY14   NPY5R   NMS   GPRC6A   PIK3R6   NPSR1   UTS2B   TAS2R42   MT-RNR2   GPR65   NPW   PROKR2   NPB   PROKR1   HCAR2   OXER1   RXFP4   RLN3   PIK3R5   ARHGEF1   KISS1R   MCHR2   P2RY11   QRFPR   OXGR1   F2RL3   LPAR4   CCL19   P2RY13   SUCNR1   HCAR1   NMUR2   NPFFR1   LPAR5   S1PR5   P2RY12   CXCL16   NMUR1   PROK2   PLCB1   CCL28   HEBP1   RXFP3   TAS2R16   TAS2R14   TAS2R13   TAS2R10   TAS2R9   TAS2R8   TAS2R7   TAS2R5   TAS2R4   TAS2R3   TAS2R1   ARHGEF12   XCL2   GHRL   TAC3   OPN4   UTS2R   GPR132   GPR55   CCL27   NPFFR2  

MLP Assay (1)

AID Type Active / Inconclusive / Inactive Description
743433 confirmatory 0 / 0 / 1 Selectivity Studies of mglur8 probe at mglur2

Gene RIF (33)

PMID Text
26758213 Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
26589404 this work offers new insights into the functioning of the mGlu2 receptor, which might contribute to the development of new and improved PAMs
25571949 Study furthers our understanding of positive allosteric modulation of the mGlu2 receptor and can contribute to improved future design of mGlu2 modulators.
25150943 Results demonstrate no changes in expression and density of both 5-HT2AR and mGlu2/3R in the postmortem prefrontal cortex of subjects with major depressive disorder under basal conditions; antidepressant treatment induces a decrease in 5-HT2AR density
24949866 Findings suggest that mGluR2/3 and mGluR5s are unaltered in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia
23407939 Human anterior cingulate cortex from alcoholic patients shows a significant reduction in mGluR(2) transcripts compared to control subjects
23149219 the promoter methylation of the GMR2 and GMR5 genes greatly decreased the risk of schizophrenia, and the expression level of the GRM2, GRM5, and GRIA3 genes increased significantly in patients in comparison to healthy controls.
23129762 Three residues located at the intracellular end of transmembrane domain four are necessary for the mGlu2 receptor binding to 5TR2A.
22988116 Only full-length dimeric mGlu2 activates G protein upon glutamate binding.
22870276 the structural properties for the H8 domain of the mGluR2 receptor; H8 behaves as a sensor of cholesterol concentration.
21881873 data support the idea that glutamate release in the vental tegmental area(VTA) is critically involved in cocaine-induced reinstatement; loss of mGluR2/3-mediated regulation of glutamate release in the VTA may critically contribute to the risk of relapse
21173788 Suggest a genetic association exists between SNPs in several genes, such as HTR2A and NRG1, and response to mGlu2/3 agonist LY2140023 treatment in schizophrenia.
20211215 Our results suggested that GRM2 may play a role in the pathophysiology of methamphetamine-induced psychosis but not schizophrenia in the Japanese population
20211215 Observational study of gene-disease association, gene-gene interaction, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19945495 This study demonistrated that the level of metabotropic glutamate receptor 2/3 is elevated in the prefrontal cortex in patient of major depression disorder.
19635471 Our findings suggest that disruption of glutamate receptors like NMDAR1 and mGluR2 at the Shank-postsynaptic platform could contribute to destruction of the postsynaptic density which underlies the synaptic dysfunction and loss in Alzheimer's disease.
19402024 The glutamate receptor metabotropic 2 mutants with increased structural flexibility at this position, which is crucial for pocket closure, were clearly preferred.
19386277 No association is detected between GRM2 and major depressive disorder or bipolar disorder in an allele/genotype-wise or haplotype-wise analysis of Japanese patients.
19386277 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19367581 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19156168 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19086053 Observational study of gene-disease association. (HuGE Navigator)
19026996 findings show that the activation of mGluR2 leads to the activation of extracellular signal-related kinase pathways
18853337 The expression of mGluR2, 3 in DA cells provide a mechanism for glutamate to modulate dopamine release in the human brain and this species-specific difference may be critical to understanding rodent models in schizophrenia.
18297054 In post-mortem human brain from untreated schizophrenic subjects, the 2AR is upregulated and the mGluR2 is downregulated, a pattern that could predispose to psychosis
16678921 The objective of this study was to assess the effects of the mGlu2/3 receptor agonist LY404039 (LY) on operant EtOH self-administration during alcohol seeking pavlovian spontaneous recovery, alcohol relapse, and maintenance responding for alcohol.
15837331 Authors have identified and synthesized a brain penetrant propanoic acid as an allosteric potentiator of the metabotropic glutamate receptor 2.
15330338 Stimulation of glial mGluR2 through mediators present in the cerebrospinal fluid may contribute to glial proliferation and astrogliosis in amyotrophic lateral sclerosis.
15246118 Reduction of mGluR2 immunopositive product in the stratum lacunosum moleculare of hippocampal CA1 is a consequence of neuronal loss in either the entorhinal cortex or CA1 area of the hippocampus.
11897108 The presynaptic group 2 metabotropic glutamate receptor reduces stimulated and spontaneous transmitter release in the dentate gyrus.
11840499 Mapped to Chromosome 3p21.1 - p21.2 and has 5 exons ranging from 74 - 1076 bp.
11641422 Ser-148 and Arg-183 may be important for the 3D structure and/or are involved in closure of the domain. Asp-146 is involved in differential binding properties of mGlur2.
11317221 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MGSLLALLALLLLWGAVAEGPAKKVLTLEGDLVLGGLFPVHQKGGPAEDCGPVNEHRGIQRLEAMLFALD      1 - 70
RINRDPHLLPGVRLGAHILDSCSKDTHALEQALDFVRASLSRGADGSRHICPDGSYATHGDAPTAITGVI     71 - 140
GGSYSDVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFFQAKAMAEILRFFNWTYVSTV    141 - 210
ASEGDYGETGIEAFELEARARNICVATSEKVGRAMSRAAFEGVVRALLQKPSARVAVLFTRSEDARELLA    211 - 280
ASQRLNASFTWVASDGWGALESVVAGSEGAAEGAITIELASYPISDFASYFQSLDPWNNSRNPWFREFWE    281 - 350
QRFRCSFRQRDCAAHSLRAVPFEQESKIMFVVNAVYAMAHALHNMHRALCPNTTRLCDAMRPVNGRRLYK    351 - 420
DFVLNVKFDAPFRPADTHNEVRFDRFGDGIGRYNIFTYLRAGSGRYRYQKVGYWAEGLTLDTSLIPWASP    421 - 490
SAGPLPASRCSEPCLQNEVKSVQPGEVCCWLCIPCQPYEYRLDEFTCADCGLGYWPNASLTGCFELPQEY    491 - 560
IRWGDAWAVGPVTIACLGALATLFVLGVFVRHNATPVVKASGRELCYILLGGVFLCYCMTFIFIAKPSTA    561 - 630
VCTLRRLGLGTAFSVCYSALLTKTNRIARIFGGAREGAQRPRFISPASQVAICLALISGQLLIVVAWLVV    631 - 700
EAPGTGKETAPERREVVTLRCNHRDASMLGSLAYNVLLIALCTLYAFKTRKCPENFNEAKFIGFTMYTTC    701 - 770
IIWLAFLPIFYVTSSDYRVQTTTMCVSVSLSGSVVLGCLFAPKLHIILFQPQKNVVSHRAPTSRFGSAAA    771 - 840
RASSSLGQGSGSQFVPTVCNGREVVDSTTSSL                                          841 - 872
//

Text Mined References (39)

PMID Year Title
26758213 2016 Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia.
26589404 2016 Molecular mechanism of positive allosteric modulation of the metabotropic glutamate receptor 2 by JNJ-46281222.
25571949 2015 Molecular determinants of positive allosteric modulation of the human metabotropic glutamate receptor 2.
25416956 2014 A proteome-scale map of the human interactome network.
25150943 2014 Evaluation of 5-HT2A and mGlu2/3 receptors in postmortem prefrontal cortex of subjects with major depressive disorder: effect of antidepressant treatment.
24949866 2014 Metabotropic glutamate receptor mGluR2/3 and mGluR5 binding in the anterior cingulate cortex in psychotic and nonpsychotic depression, bipolar disorder and schizophrenia: implications for novel mGluR-based therapeutics.
24080311 2014 Glutamate receptors and the regulation of steroidogenesis in the human adrenal gland: the metabotropic pathway.
23407939 2013 Rescue of infralimbic mGluR2 deficit restores control over drug-seeking behavior in alcohol dependence.
23149219 2013 Evaluation of hypermethylation and expression pattern of GMR2, GMR5, GMR8, and GRIA3 in patients with schizophrenia.
23129762 2012 Identification of three residues essential for 5-hydroxytryptamine 2A-metabotropic glutamate 2 (5-HT2A·mGlu2) receptor heteromerization and its psychoactive behavioral function.
22988116 2012 Distinct roles of metabotropic glutamate receptor dimerization in agonist activation and G-protein coupling.
22870276 2012 Membrane-sensitive conformational states of helix 8 in the metabotropic Glu2 receptor, a class C GPCR.
22300836 2012 Heterocomplex formation of 5-HT2A-mGlu2 and its relevance for cellular signaling cascades.
21881873 2012 Regulation of cocaine-induced reinstatement by group II metabotropic glutamate receptors in the ventral tegmental area.
21173788 2012 Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.
20211215 2010 Association analysis of GRM2 and HTR2A with methamphetamine-induced psychosis and schizophrenia in the Japanese population.
19945495 2010 Elevated level of metabotropic glutamate receptor 2/3 in the prefrontal cortex in major depression.
19635471 2009 Disruption of glutamate receptors at Shank-postsynaptic platform in Alzheimer's disease.
19402024 2009 Mutagenesis and molecular modeling of the orthosteric binding site of the mGlu2 receptor determining interactions of the group II receptor antagonist (3)H-HYDIA.
19386277 2009 Association analysis of group II metabotropic glutamate receptor genes (GRM2 and GRM3) with mood disorders and fluvoxamine response in a Japanese population.
19367581 2010 Identification of neuroglycan C and interacting partners as potential susceptibility genes for schizophrenia in a Southern Chinese population.
19156168 2009 Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
19086053 2009 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
19026996 2009 The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival.
18853337 2008 Metabotropic glutamate receptor 2 and 3 gene expression in the human prefrontal cortex and mesencephalon in schizophrenia.
18297054 2008 Identification of a serotonin/glutamate receptor complex implicated in psychosis.
16678921 2006 The metabotropic glutamate 2/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15837331 2005 3-(2-Ethoxy-4-{4-[3-hydroxy-2-methyl-4-(3-methylbutanoyl)phenoxy]butoxy}phenyl)propanoic acid: a brain penetrant allosteric potentiator at the metabotropic glutamate receptor 2 (mGluR2).
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15330338 2004 Glial proliferation and metabotropic glutamate receptor expression in amyotrophic lateral sclerosis.
15246118 Metabotropic glutamate receptor 2/3 in the hippocampus of patients with mesial temporal lobe epilepsy, and of rats and mice after pilocarpine-induced status epilepticus.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11641422 2001 Identification of essential residues involved in the glutamate binding pocket of the group II metabotropic glutamate receptor.
11317221 2001 Structure and polymorphisms of the human metabotropic glutamate receptor type 2 gene (GRM2): analysis of association with schizophrenia.
9651375 1998 GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain.
8863838 1996 Coupling of metabotropic glutamate receptors 2 and 4 to G alpha 15, G alpha 16, and chimeric G alpha q/i proteins: characterization of new antagonists.
8824806 1996 Localization of two metabotropic glutamate receptor genes, GRM3 and GRM8, to human chromosome 7q.
7620613 1995 Molecular cloning, functional expression and pharmacological characterization of the human metabotropic glutamate receptor type 2.