| Tclin | Glutamate receptor ionotropic, NMDA 3A |
NMDA receptor subtype of glutamate-gated ion channels with reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. Mediated by glycine. May play a role in the development of dendritic spines. May play a role in PPP2CB-NMDAR mediated signaling mechanism (By similarity).
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]
This gene encodes a subunit of the N-methyl-D-aspartate (NMDA) receptors, which belong to the superfamily of glutamate-regulated ion channels, and function in physiological and pathological processes in the central nervous system. This subunit shows greater than 90% identity to the corresponding subunit in rat. Studies in the knockout mouse deficient in this subunit suggest that this gene may be involved in the development of synaptic elements by modulating NMDA receptor activity. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Erectile dysfunction | 32 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Schizophrenia | 1160 |
| Bipolar Disorder | 666 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 5.3e-51 |
| glioblastoma | 5792 | 5.2e-08 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.3e-06 |
| Astrocytoma, Pilocytic | 3081 | 1.9e-05 |
| astrocytic glioma | 2597 | 2.0e-03 |
| adult high grade glioma | 3801 | 4.5e-03 |
| primitive neuroectodermal tumor | 3035 | 4.5e-03 |
| medulloblastoma | 720 | 5.0e-03 |
| ependymoma | 4679 | 6.3e-03 |
| medulloblastoma, large-cell | 6241 | 5.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cardiovascular system disease | 246 | 0.0 | 3.0 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -2.300 | 4.5e-03 |
| astrocytic glioma | -1.700 | 2.0e-03 |
| Astrocytoma, Pilocytic | -2.700 | 1.9e-05 |
| atypical teratoid / rhabdoid tumor | -3.100 | 1.3e-06 |
| ependymoma | -1.500 | 6.3e-03 |
| glioblastoma | -2.500 | 5.2e-08 |
| medulloblastoma | -2.300 | 5.0e-03 |
| medulloblastoma, large-cell | -2.100 | 5.0e-02 |
| primitive neuroectodermal tumor | -2.600 | 4.5e-03 |
| psoriasis | -1.500 | 5.3e-51 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MRRLSLWWLLSRVCLLLPPPCALVLAGVPSSSSHPQPCQILKRIGHAVRVGAVHLQPWTTAPRAASRAPD 1 - 70 DSRAGAQRDEPEPGTRRSPAPSPGARWLGSTLHGRGPPGSRKPGEGARAEALWPRDALLFAVDNLNRVEG 71 - 140 LLPYNLSLEVVMAIEAGLGDLPLLPFSSPSSPWSSDPFSFLQSVCHTVVVQGVSALLAFPQSQGEMMELD 141 - 210 LVSLVLHIPVISIVRHEFPRESQNPLHLQLSLENSLSSDADVTVSILTMNNWYNFSLLLCQEDWNITDFL 211 - 280 LLTQNNSKFHLGSIINITANLPSTQDLLSFLQIQLESIKNSTPTVVMFGCDMESIRRIFEITTQFGVMPP 281 - 350 ELRWVLGDSQNVEELRTEGLPLGLIAHGKTTQSVFEHYVQDAMELVARAVATATMIQPELALIPSTMNCM 351 - 420 EVETTNLTSGQYLSRFLANTTFRGLSGSIRVKGSTIVSSENNFFIWNLQHDPMGKPMWTRLGSWQGGKIV 421 - 490 MDYGIWPEQAQRHKTHFQHPSKLHLRVVTLIEHPFVFTREVDDEGLCPAGQLCLDPMTNDSSTLDSLFSS 491 - 560 LHSSNDTVPIKFKKCCYGYCIDLLEKIAEDMNFDFDLYIVGDGKYGAWKNGHWTGLVGDLLRGTAHMAVT 561 - 630 SFSINTARSQVIDFTSPFFSTSLGILVRTRDTAAPIGAFMWPLHWTMWLGIFVALHITAVFLTLYEWKSP 631 - 700 FGLTPKGRNRSKVFSFSSALNICYALLFGRTVAIKPPKCWTGRFLMNLWAIFCMFCLSTYTANLAAVMVG 701 - 770 EKIYEELSGIHDPKLHHPSQGFRFGTVRESSAEDYVRQSFPEMHEYMRRYNVPATPDGVEYLKNDPEKLD 771 - 840 AFIMDKALLDYEVSIDADCKLLTVGKPFAIEGYGIGLPPNSPLTANISELISQYKSHGFMDMLHDKWYRV 841 - 910 VPCGKRSFAVTETLQMGIKHFSGLFVLLCIGFGLSILTTIGEHIVYRLLLPRIKNKSKLQYWLHTSQRLH 911 - 980 RAINTSFIEEKQQHFKTKRVEKRSNVGPRQLTVWNTSNLSHDNRRKYIFSDEEGQNQLGIRIHQDIPLPP 981 - 1050 RRRELPALRTTNGKADSLNVSRNSVMQELSELEKQIQVIRQELQLAVSRKTELEEYQRTSRTCES 1051 - 1115 //
