Property Summary

NCBI Gene PubMed Count 39
PubMed Score 145.39
PubTator Score 57.01

Knowledge Summary

Patent (5,328)

Expression

  Differential Expression (9)

Disease log2 FC p
glioblastoma -2.200 2.6e-10
group 4 medulloblastoma -2.000 1.9e-04
atypical teratoid/rhabdoid tumor -2.400 9.6e-10
medulloblastoma, large-cell -1.800 9.8e-03
primitive neuroectodermal tumor -2.200 1.8e-03
pediatric high grade glioma -2.400 6.5e-07
pilocytic astrocytoma -2.200 3.3e-07
primary Sjogren syndrome -1.300 7.8e-03
subependymal giant cell astrocytoma -2.469 1.7e-02

Gene RIF (51)

PMID Text
26289945 Findings indicate that SNPs in the GRIN2C gene is associated with altered cue-induced brain activation that is related to craving for alcohol and relapse risk.
26229101 these findings highlight the isoform-specific structural and functional differences within the 14-3-3 family of proteins, which determine GluN2C binding and its essential role in targeting the receptor to the cell surface
25788577 NMDARs have a dual role during erythropoiesis, supporting survival of polychromatic erythroblasts and contributing to the Ca(2+) homeostasis from the orthochromatic erythroblast stage to circulating red blood cells.
25760043 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
25613138 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
24925192 The major depression subjects exhibited significantly higher expression levels of the NMDA receptor subunit genes GRIN2C.
24739951 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
24102971 TNFalpha significantly upregulates NMDA-R2C mRNA expression, in differentiated, confluent, normal keratinocytes but not in involved or uninvolved psoriatic keratinocyte monolayers
24086760 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
23665428 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
23267846 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
23070074 Reduction in NR1 and NR2C in the DLPFC of people with schizophrenia may lead to altered NMDAR stoichiometry and provides compelling evidence for an endogenous NMDAR deficit in schizophrenia.
22940423 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
22833210 Functional compensation could occur to counteract the loss of one allele in GRIN2C and GRIN3 family genes.
22552781 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
22114277 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
21948112 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
21670103 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
21491143 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
19874574 Observational study of gene-disease association. (HuGE Navigator)
19526283 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
19156168 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19036954 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
19020013 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
18444252 Observational study of gene-disease association. (HuGE Navigator)
17360663 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
16697675 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
16489129 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
16481105 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
15749123 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
14644469 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
12775422 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
12414113 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
12082569 Observational study of gene-disease association. (HuGE Navigator)
11606043 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
11483648 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
10555109 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
10448428 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
10197777 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
9745929 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
9651389 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8955056 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8845955 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8822372 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8821747 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8804048 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8724036 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8581564 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
8563977 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
7695237 The gene expression of GRIN2C is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells
1350383 The authors identified and cloned sequences of NMDA receptor subunits 2A, 2B, and 2C from rat. They characterized the properties of the receptors composed of heteromeric 1-2A and heteromeric 1-2C and found that the latter had reduced sensitivity to magnesium and smaller conductance compared to the former.

AA Sequence

MGGALGPALLLTSLFGAWAGLGPGQGEQGMTVAVVFSSSGPPQAQFRARLTPQSFLDLPLEIQPLTVGVN      1 - 70
TTNPSSLLTQICGLLGAAHVHGIVFEDNVDTEAVAQILDFISSQTHVPILSISGGSAVVLTPKEPGSAFL     71 - 140
QLGVSLEQQLQVLFKVLEEYDWSAFAVITSLHPGHALFLEGVRAVADASHVSWRLLDVVTLELGPGGPRA    141 - 210
RTQRLLRQLDAPVFVAYCSREEAEVLFAEAAQAGLVGPGHVWLVPNLALGSTDAPPATFPVGLISVVTES    211 - 280
WRLSLRQKVRDGVAILALGAHSYWRQHGTLPAPAGDCRVHPGPVSPAREAFYRHLLNVTWEGRDFSFSPG    281 - 350
GYLVQPTMVVIALNRHRLWEMVGRWEHGVLYMKYPVWPRYSASLQPVVDSRHLTVATLEERPFVIVESPD    351 - 420
PGTGGCVPNTVPCRRQSNHTFSSGDVAPYTKLCCKGFCIDILKKLARVVKFSYDLYLVTNGKHGKRVRGV    421 - 490
WNGMIGEVYYKRADMAIGSLTINEERSEIVDFSVPFVETGISVMVARSNGTVSPSAFLEPYSPAVWVMMF    491 - 560
VMCLTVVAITVFMFEYFSPVSYNQNLTRGKKSGGPAFTIGKSVWLLWALVFNNSVPIENPRGTTSKIMVL    561 - 630
VWAFFAVIFLASYTANLAAFMIQEQYIDTVSGLSDKKFQRPQDQYPPFRFGTVPNGSTERNIRSNYRDMH    631 - 700
THMVKFNQRSVEDALTSLKMGKLDAFIYDAAVLNYMAGKDEGCKLVTIGSGKVFATTGYGIAMQKDSHWK    701 - 770
RAIDLALLQFLGDGETQKLETVWLSGICQNEKNEVMSSKLDIDNMAGVFYMLLVAMGLALLVFAWEHLVY    771 - 840
WKLRHSVPNSSQLDFLLAFSRGIYSCFSGVQSLASPPRQASPDLTASSAQASVLKMLQAARDMVTTAGVS    841 - 910
SSLDRATRTIENWGGGRRAPPPSPCPTPRSGPSPCLPTPDPPPEPSPTGWGPPDGGRAALVRRAPQPPGR    911 - 980
PPTPGPPLSDVSRVSRRPAWEARWPVRTGHCGRHLSASERPLSPARCHYSSFPRADRSGRPFLPLFPELE    981 - 1050
DLPLLGPEQLARREALLHAAWARGSRPRHASLPSSVAEAFARPSSLPAGCTGPACARPDGHSACRRLAQA   1051 - 1120
QSMCLPIYREACQEGEQAGAPAWQHRQHVCLHAHAHLPFCWGAVCPHLPPCASHGSWLSGAWGPLGHRGR   1121 - 1190
TLGLGTGYRDSGGLDEISRVARGTQGFPGPCTWRRISSLESEV                              1191 - 1233
//

Text Mined References (42)

PMID Year Title
26289945 2015 The effects of single nucleotide polymorphisms in glutamatergic neurotransmission genes on neural response to alcohol cues and craving.
26229101 2015 Identification of Novel 14-3-3 Residues That Are Critical for Isoform-specific Interaction with GluN2C to Regulate N-Methyl-D-aspartate (NMDA) Receptor Trafficking.
25788577 2015 Functional plasticity of the N-methyl-d-aspartate receptor in differentiating human erythroid precursor cells.
24925192 2014 Elevated gene expression of glutamate receptors in noradrenergic neurons from the locus coeruleus in major depression.
24102971 2013 Psoriatic keratinocytes are resistant to tumor necrosis factor alpha's induction of mRNA for the NMDA-R2C subunit.
23070074 2013 Molecular evidence of N-methyl-D-aspartate receptor hypofunction in schizophrenia.
22833210 2011 Rare mutations in N-methyl-D-aspartate glutamate receptors in autism spectrum disorders and schizophrenia.
22343826 2013 Diversity in NMDA receptor composition: many regulators, many consequences.
22245680 2012 Influence of the intracellular GluN2 C-terminal domain on NMDA receptor function.
22197913 2012 Molecular pharmacology of human NMDA receptors.
21919190 2011 Association of GRIN1 and GRIN2A-D with schizophrenia and genetic interaction with maternal herpes simplex virus-2 infection affecting disease risk.
21807990 2011 Mechanism for noncompetitive inhibition by novel GluN2C/D N-methyl-D-aspartate receptor subunit-selective modulators.
21300787 2011 Deficiency of sorting nexin 27 (SNX27) leads to growth retardation and elevated levels of N-methyl-D-aspartate receptor 2C (NR2C).
21152063 2010 Characterisation of the expression of NMDA receptors in human astrocytes.
20981015 2010 A subunit-selective potentiator of NR2C- and NR2D-containing NMDA receptors.
20976280 2010 Evolutionary mode and functional divergence of vertebrate NMDA receptor subunit 2 genes.
19874574 2009 Genetical genomic determinants of alcohol consumption in rats and humans.
19477150 2009 Growth factor-dependent trafficking of cerebellar NMDA receptors via protein kinase B/Akt phosphorylation of NR2C.
19156168 2009 Pharmacogenetics of antipsychotic response in the CATIE trial: a candidate gene analysis.
18444252 2008 Neurotransmission and bipolar disorder: a systematic family-based association study.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
16625196 2006 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
16606616 2006 Regulation of NR1/NR2C N-methyl-D-aspartate (NMDA) receptors by phosphorylation.
15920498 2005 Elevated levels of the NR2C subunit of the NMDA receptor in the locus coeruleus in depression.
15494561 2004 Role of distinct NMDA receptor subtypes at central synapses.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15287897 2004 Differential expression of N-methyl-D-aspartate receptor NR2 isoforms in Alzheimer's disease.
12815021 2003 Activation of peripheral NMDA receptors contributes to human pain and rat afferent discharges evoked by injection of glutamate into the masseter muscle.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12082569 2002 Determination of the genomic structure and mutation screening in schizophrenic individuals for five subunits of the N-methyl-D-aspartate glutamate receptor.
11937501 2002 Selectivity and promiscuity of the first and second PDZ domains of PSD-95 and synapse-associated protein 102.
11854440 2002 Intracellular domains of NR2 alter calcium-dependent inactivation of N-methyl-D-aspartate receptors.
10943672 2000 N-methyl-D-aspartate receptor subunit mRNA expression in human retinal ganglion cells.
10648872 2000 Ionotropic glutamate receptor expression in human spinal cord during first trimester development.
9798920 1998 The human N-methyl-D-aspartate receptor 2C subunit: genomic analysis, distribution in human brain, and functional expression.
9480759 1998 Localization of the human NMDAR2D receptor subunit gene (GRIN2D) to 19q13.1-qter, the NMDAR2A subunit gene to 16p13.2 (GRIN2A), and the NMDAR2C subunit gene (GRIN2C) to 17q24-q25 using somatic cell hybrid and radiation hybrid mapping panels.
9037519 1996 Cloning of the cDNA for the human NMDA receptor NR2C subunit and its expression in the central nervous system and periphery.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
8665664 1995 Developmental rearrangements of cortical glutamate-NMDA receptor binding sites in late human gestation.
8267632 1993 Chromosomal localization of the epsilon 1, epsilon 3 and zeta 1 subunit genes of the human NMDA receptor channel.
7695237 1995 Human immunodeficiency virus type 1 tat activates non-N-methyl-D-aspartate excitatory amino acid receptors and causes neurotoxicity.
1350383 1992 Heteromeric NMDA receptors: molecular and functional distinction of subtypes.