Property Summary

NCBI Gene PubMed Count 32
PubMed Score 28.20
PubTator Score 45.02

Knowledge Summary

Patent (3,056)

Expression

  Differential Expression (8)

Disease log2 FC p
astrocytic glioma 1.200 4.5e-02
ependymoma -2.000 8.3e-09
group 4 medulloblastoma -2.700 1.0e-07
atypical teratoid / rhabdoid tumor -1.600 2.0e-02
medulloblastoma, large-cell -1.800 2.0e-04
pilocytic astrocytoma 2.000 1.0e-04
lung carcinoma 2.800 7.0e-41
psoriasis -1.300 5.2e-41

 MGI Phenotype (1)

 CSPA Cell Line (2)

Protein-protein Interaction (7)

Gene RIF (29)

PMID Text
24449200 1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
23006490 Analyses revealed that polymorphism Ser310Ala of GRIK3 gene is not associated with alcohol dependence or any of its subgroups.
22232963 Our results suggest that the analysed polymorphisms ofANKK1 and ADH4 can play an important part in the pathogenesis of alcohol abuse
20859245 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20052609 Some support (at a nominal significance level of 0.05/0.01) was found for association between GRIK3 and depression.
19995671 Observational study of gene-disease association. (HuGE Navigator)
19921975 Our study suggests a potential role for GRIK3 for susceptibility to schizophrenia in Indian population.
19921975 Observational study of gene-disease association. (HuGE Navigator)
19320626 Observational study of gene-disease association. (HuGE Navigator)
19221446 functional GRIK3 Ser310Ala polymorphism is homozygosity is associated with higher scores in harm avoidance and respective subscales of personality traits
19221446 Observational study of gene-disease association. (HuGE Navigator)
19125103 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
19086053 Observational study of gene-disease association. (HuGE Navigator)
19022628 The present results, although not robust, support the importance of more extensive investigations of GRIK3, given its potential role in mediating risk for schizophrenia.
19022628 Observational study of gene-disease association. (HuGE Navigator)
18423838 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
16958029 Observational study of gene-disease association. (HuGE Navigator)
16958029 significant linkage disequilibrium (LD) indicated by preferential maternal transmission of the GluR7 S310 allele to recurrent major depressive disorder patients (P = 0.012), but not to bipolar I disorder (BPI) patients (P = 1.00)
16356644 Observational study of gene-disease association. (HuGE Navigator)
16356644 These findings do not seem to support the hypothesis of the role of this polymorphism in the pathogenesis of alcoholism.
16325263 Observational study of gene-disease association. (HuGE Navigator)
16314883 Observational study of gene-disease association. (HuGE Navigator)
16314883 suggestive for a significant role of GRIK3 polymorphism in the pathogenesis of delirium tremens in alcohol-dependent individuals
15897672 Observational study of gene-disease association. (HuGE Navigator)
15094479 Observational study of gene-disease association. (HuGE Navigator)
15094479 Using three single nucleotide polymorphisms in GRIK2 and one in GRIK3, we found no evidence for association with Obssessive-Compulsive disorder in case-control or family-based analyses.
11986986 Observational study of gene-disease association. (HuGE Navigator)
11986986 Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia.

AA Sequence

MTAPWRRLRSLVWEYWAGLLVCAFWIPDSRGMPHVIRIGGIFEYADGPNAQVMNAEEHAFRFSANIINRN      1 - 70
RTLLPNTTLTYDIQRIHFHDSFEATKKACDQLALGVVAIFGPSQGSCTNAVQSICNALEVPHIQLRWKHH     71 - 140
PLDNKDTFYVNLYPDYASLSHAILDLVQYLKWRSATVVYDDSTGLIRLQELIMAPSRYNIRLKIRQLPID    141 - 210
SDDSRPLLKEMKRGREFRIIFDCSHTMAAQILKQAMAMGMMTEYYHFIFTTLDLYALDLEPYRYSGVNLT    211 - 280
GFRILNVDNPHVSAIVEKWSMERLQAAPRSESGLLDGVMMTDAALLYDAVHIVSVCYQRAPQMTVNSLQC    281 - 350
HRHKAWRFGGRFMNFIKEAQWEGLTGRIVFNKTSGLRTDFDLDIISLKEDGLEKVGVWSPADGLNITEVA    351 - 420
KGRGPNVTDSLTNRSLIVTTVLEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGK    421 - 490
YGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNP    491 - 560
LSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMP    561 - 630
KALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSK    631 - 700
ISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTP    701 - 770
MGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAV    771 - 840
GEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKTDAVINMHTFNDRRLPGKDSMAC    841 - 910
STSLAPVFP                                                                 911 - 919
//

Text Mined References (34)

PMID Year Title
24449200 2014 1p34.3 deletion involving GRIK3: Further clinical implication of GRIK family glutamate receptors in the pathogenesis of developmental delay.
23894747 2013 A comprehensive family-based replication study of schizophrenia genes.
23006490 2013 Family-based and case-control study of glutamate receptor GRIK3 Ser310Ala polymorphism in alcohol dependence.
22232963 [Research on associations between selected polymorphisms of genes DRD2, 5HTT, GRIK3, ADH4 and alcohol dependence syndrome].
20859245 2011 Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20052609 2010 Association of existing and new candidate genes for anxiety, depression and personality traits in older people.
19995671 2010 Are GRIK3 (T928G) gene variants in schizophrenia patients different from those in their first-degree relatives?
19921975 2009 Association between the ionotropic glutamate receptor kainate3 (GRIK3) Ser310Ala polymorphism and schizophrenia in the Indian population.
19342380 2009 Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.
19320626 2009 Association of markers in the 3' region of the GluR5 kainate receptor subunit gene to alcohol dependence.
19221446 2009 An association of GRIK3 Ser310Ala functional polymorphism with personality traits.
19125103 2009 Association analysis of the glutamic acid decarboxylase 2 and the glutamine synthetase genes (GAD2, GLUL) with schizophrenia.
19086053 2009 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
19022628 2009 A possible association between schizophrenia and GRIK3 polymorphisms in a multicenter sample of Scandinavian origin (SCOPE).
18423838 2008 Synergistic effects of the dopaminergic and glutamatergic system on hippocampal volume in alcohol-dependent patients.
17213182 2006 Identification of genes related to Parkinson's disease using expressed sequence tags.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16958029 2007 Association of the human kainate receptor GluR7 gene (GRIK3) with recurrent major depressive disorder.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
16356644 2006 Family-based and case-control association studies of glutamate receptor GRIK3 Ser310Ala polymorphism in Polish patients and families with alcohol dependence.
16325263 2006 Association study of polymorphisms in the GluR7, KA1 and KA2 kainate receptor genes (GRIK3, GRIK4, GRIK5) with schizophrenia.
16314883 Ionotropic glutamate receptor gene GRIK3 SER310ALA functional polymorphism is related to delirium tremens in alcoholics.
15897672 2005 No association between the ionotropic glutamate receptor kainate 3 gene ser310ala polymorphism and schizophrenia.
15094479 2004 Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.
11986986 2002 Association between the ionotropic glutamate receptor kainate 3 (GRIK3) ser310ala polymorphism and schizophrenia.
11943148 2002 The actin-binding protein Filamin-A interacts with the metabotropic glutamate receptor type 7.
11124978 2000 Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains.
10737800 2000 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.
9466455 1998 Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.
9144652 1997 A novel splice variant of a metabotropic glutamate receptor, human mGluR7b.
8163463 1994 Transmembrane topology of the glutamate receptor subunit GluR6.
8128318 1993 Chromosomal localization of gene for human glutamate receptor subunit-7.
7719709 1994 Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites.