Property Summary

NCBI Gene PubMed Count 85
PubMed Score 265.60
PubTator Score 198.67

Knowledge Summary

Patent (72,362)

TINX Plot

  Disease (8)

Expression

  Differential Expression (15)

Disease log2 FC p
malignant mesothelioma -2.400 3.5e-07
astrocytic glioma 1.800 8.7e-03
oligodendroglioma 2.400 2.1e-02
osteosarcoma 1.908 2.7e-02
posterior fossa group A ependymoma -2.800 3.5e-11
glioblastoma -2.200 9.0e-04
group 4 medulloblastoma -2.600 1.1e-04
atypical teratoid / rhabdoid tumor -2.500 3.4e-04
medulloblastoma, large-cell 2.800 2.5e-04
lung cancer 3.700 9.4e-05
pediatric high grade glioma -1.500 4.8e-03
non primary Sjogren syndrome sicca -1.400 2.0e-02
subependymal giant cell astrocytoma -2.955 4.7e-02
lung carcinoma 3.500 2.2e-42
ovarian cancer -1.500 2.1e-08

 GWAS Trait (1)

Protein-protein Interaction (4)

Gene RIF (53)

PMID Text
27324535 In the Han population in Central China, the polymorphisms of SNP rs9390754 in the GRIK2 gene may be associated with epilepsy susceptibility.
26277340 Study demonstrates that co-assembly of recombinant kainate receptors (GluK1 and GluK2) with the Neto1 and Neto2 auxiliary subunits alters their onset and recovery from desensitization in a subunit-dependent manner
25842862 High risk genetic markers of paranoid schizophrenia were GRIK2*ATG and GRIK2*TGG in Tatars.
25316086 Parkin interacts with the kainate receptor GluK2 subunit and regulates KAR function.
25201974 The present study reveals an additional mechanism for the regulation of GluK2-containing kainate receptors by Src family kinases, which may be of pathological significance in ischemic stroke.
24821223 This study showed that Gluk2 association with obsessive-compulsive disorder.
24662927 This study found in GRIK2 (glutamate receptor, ionotropic kainate 2) was most significant and also showed significant correlations with gene expression.
23861400 14-3-3 proteins are an important regulator of GluK2a-containing KARs and may contribute to the slow decay kinetics of native KAR-EPSCs.
23713029 Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state.
23660601 we found no association between rs1556995 in GRIK2 and clozapine-induced obsessive-compulsive (OC) symptoms, implying that that GRIK2 may not play a role in the development of OC symptoms in schizophrenia patients
23400781 Kainate receptor GluK2a post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis
23037145 Eight chromosome 6 SNPs, having the most significant differences, were delineated: rs10499298, rs10499299, rs17827966, rs1224329, rs1150790, rs713050, rs2518344 and rs487083; all were associated with genes GRIK2.
22771793 Comprehensive analytical methods applied to a much larger sample than in previous studies do not support a role for GRIK2 as a genetic modifier of age at onset of clinical symptoms in Huntington's disease.
22429480 The ACAG haplotype in the 13th haplotype block of the GRIK2 gene was associated with somatic anxiety.
21912186 Convergent functional genomics allowed the identification of novel candidate genes, GRIK2 and NPAS2, involved in glutamatergic neurotransmission and the circadian rhythm, respectively, that are potentially associated with CFS.
21557188 Genotyping and linkage analysis excluded linkage of the GRIK2 gene and TUSC3 gene with mental retardation.
20863077 human GluK2 is a slowly activating channel but more sensitive to glutamate, as compared to the rat ortholog; the M867I mutation does not affect the rate the equilibrium constants of the channel opening but does slow down the channel desensitization rate
20859245 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20442744 Observational study and meta-analysis of gene-disease association. (HuGE Navigator)
20379614 Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
20370803 This study supports previously reported findings of association between proximal GRIK2 single nucleotide polymorphism and obsessive-compulsive disorder in a comprehensive evaluation of the gene
20370803 Observational study of gene-disease association. (HuGE Navigator)
20230879 Spliced variants of ionotropic glutamate receptor GluR6 is associated with astrocytoma.
19920140 phosphorylation of PKC sites on GluR6 regulates surface expression of GluR6 at distinct intracellular trafficking pathways
19617541 Results indicate that ions can contribute substantial free energy to active state stabilization in GluR6, and provide quantitative measurements of the energetic consequences of allosteric ion binding to a ligand-gated ion channel.
19295509 Clinical trial of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19268276 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
19260141 Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)
19225180 in silico ligand-docking predicted that most partial agonists select for the closed and not, as expected, the open or intermediate conformations of the GluK2 agonist binding domain.
19086053 Observational study of gene-disease association. (HuGE Navigator)
18692513 GluR6 C-terminal domain KRIP6 regulates kainate receptors by inhibiting PICK1 modulation via competition or a mutual blocking effect
18690046 nonconserved residues in GluR6 define the size of the agonist-binding pocket, exerting a steric influence on the bound agonist and the extent of binding-domain closure
18664604 Mutations to GLUR6 binding pocket that selectively affect domoate binding are freported.
18658129 the apo state of GluR6 undergoes a cleft closure of 29-30 degrees upon binding full agonists, one of the largest observed in the glutamate receptor family.
18593792 results support the involvement of genes GRIA3 and GRIK2 in antidepressant treatment-emergent suicidal ideation
18519826 Clinical trial and genome-wide association study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
18289788 Overall, our data indicate that hGluR6c might have unique properties in non-nervous cells and in the first stages of CNS development.
17847003 report a complex mutation in the ionotropic glutamate receptor 6 gene (GRIK2, also called "GLUR6") that cosegregates with moderate-to-severe nonsyndromic autosomal recessive mental retardation in a large, consanguineous Iranian family
17712621 Mutations of GluR6 are unlikely to be associated with autism in the Indian population.
17712621 Observational study of gene-disease association. (HuGE Navigator)
17428563 Observational study of gene-disease association. (HuGE Navigator)
17428563 These results suggest a potential association between GRIK2 and autism in the Korean population.
17379418 phosphorylation of the C-terminal tail of GluR6 by PKA leads to potentiation of whole cell response
17167233 Our data on altered functional properties of GluR6(M836I) provide a functional basis for the postulated linkage of GluR6 to autism.
16959037 The modifier effect is actually due to the TAA repeat itself, possibly via a functional consequence on the GRIK2 mRNA.
16847693 Observational study of gene-disease association. (HuGE Navigator)
15305151 In this study, the maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia.
15094479 Observational study of gene-disease association. (HuGE Navigator)
15094479 Using three single nucleotide polymorphisms in GRIK2 and one in GRIK3, we found no evidence for association with Obssessive-Compulsive disorder in case-control or family-based analyses.
14567698 describes the time course of the open-channel form of the receptor as a function of glutamate concentration
12821179 Specific alleles in GluR6 and CA150 locus were only observed in HD patients.
12467946 Observational study of gene-disease association. (HuGE Navigator)
11920157 Linkage and association of the glutamate receptor 6 gene with autism

AA Sequence

MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTL      1 - 70
LPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSD     71 - 140
NKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKD    141 - 210
AKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFR    211 - 280
ILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTTDAALMYDAVHVVSVAVQQFPQMTVSSLQCNRH    281 - 350
KPWRFGTRFMSLIKEAHWEGLTGRITFNKTNGLRTDFDLDVISLKEEGLEKIGTWDPASGLNMTESQKGK    351 - 420
PANITDSLSNRSLIVTTILEEPYVLFKKSDKPLYGNDRFEGYCIDLLRELSTILGFTYEIRLVEDGKYGA    421 - 490
QDDANGQWNGMVRELIDHKADLAVAPLAITYVREKVIDFSKPFMTLGISILYRKPNGTNPGVFSFLNPLS    491 - 560
PDIWMYILLAYLGVSCVLFVIARFSPYEWYNPHPCNPDSDVVENNFTLLNSFWFGVGALMQQGSELMPKA    561 - 630
LSTRIVGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVEDGATMTFFKKSKIS    631 - 700
TYDKMWAFMSSRRQSVLVKSNEEGIQRVLTSDYAFLMESTTIEFVTQRNCNLTQIGGLIDSKGYGVGTPM    701 - 770
GSPYRDKITIAILQLQEEGKLHMMKEKWWRGNGCPEEESKEASALGVQNIGGIFIVLAAGLVLSVFVAVG    771 - 840
EFLYKSKKNAQLEKRSFCSAMVEELRMSLKCQRRLKHKPQAPVIVKTEEVINMHTFNDRRLPGKETMA      841 - 908
//

Text Mined References (89)

PMID Year Title
27324535 2016 [Association between glutamate receptor 2 polymorphisms and epilepsy in children].
26277340 2015 The auxiliary subunits Neto1 and Neto2 have distinct, subunit-dependent effects at recombinant GluK1- and GluK2-containing kainate receptors.
25842862 [Glutamate receptors genes polymorphism and the risk of paranoid schizophrenia in Russians and tatars from the Republic of Bashkortostan].
25316086 2014 Parkin regulates kainate receptors by interacting with the GluK2 subunit.
25201974 2014 Tyrosine phosphorylation of GluK2 up-regulates kainate receptor-mediated responses and downstream signaling after brain ischemia.
25199915 2015 GWAS of longevity in CHARGE consortium confirms APOE and FOXO3 candidacy.
24821223 2015 Genome-wide association study in obsessive-compulsive disorder: results from the OCGAS.
24662927 2015 Astrocytic abnormalities and global DNA methylation patterns in depression and suicide.
23861400 2013 Modulation of GluK2a subunit-containing kainate receptors by 14-3-3 proteins.
23713029 2013 Crosslinking the ligand-binding domain dimer interface locks kainate receptors out of the main open state.
23660601 2013 Influence of polymorphisms in genes SLC1A1, GRIN2B, and GRIK2 on clozapine-induced obsessive-compulsive symptoms.
23400781 2013 Kainate receptor post-translational modifications differentially regulate association with 4.1N to control activity-dependent receptor endocytosis.
23362303 2013 Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.
23251661 2012 Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
23037145 2013 Association of genes on chromosome 6, GRIK2 , TMEM217 and TMEM63B (linked to MRPL14 ) with diabetic retinopathy.
22889921 2013 Genome-wide association study of obsessive-compulsive disorder.
22808340 2012 Modification and movement: Phosphorylation and SUMOylation regulate endocytosis of GluK2-containing kainate receptors.
22797727 2012 Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.
22771793 2012 TAA repeat variation in the GRIK2 gene does not influence age at onset in Huntington's disease.
22429480 2012 Genetic association study of individual symptoms in depression.
21912186 2011 Convergent genomic studies identify association of GRIK2 and NPAS2 with chronic fatigue syndrome.
21893069 2011 Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors.
21557188 2011 Non-syndromic autosomal recessive mental retardation in Tunisian families : exclusion of GRIK2 and TUSC3 genes.
21348951 2011 Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
20863077 2010 Channel-opening kinetic mechanism for human wild-type GluK2 and the M867I mutant kainate receptor.
20859245 2011 Glutamatergic gene variants impact the clinical profile of efficacy and side effects of haloperidol.
20442744 2010 Linkage and candidate gene studies of autism spectrum disorders in European populations.
20379614 Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
20370803 2011 Association between polymorphisms in GRIK2 gene and obsessive-compulsive disorder: a family-based study.
20230879 2010 Novel spliced variants of ionotropic glutamate receptor GluR6 in normal human fibroblast and brain cells are transcribed by tissue specific promoters.
19920140 2010 Differential regulation of kainate receptor trafficking by phosphorylation of distinct sites on GluR6.
19617541 2009 Energetics of glutamate receptor ligand binding domain dimer assembly are modulated by allosteric ions.
19342380 2009 Glutamate binding and conformational flexibility of ligand-binding domains are critical early determinants of efficient kainate receptor biogenesis.
19295509 2009 Genetic and clinical predictors of sexual dysfunction in citalopram-treated depressed patients.
19268276 2009 Genome-wide association study of smoking initiation and current smoking.
19260141 2009 Genome-wide association study of biochemical traits in Korcula Island, Croatia.
19225180 2009 Functional characterization and in silico docking of full and partial GluK2 kainate receptor agonists.
19086053 2009 Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.
18692513 2008 The BTB/kelch protein, KRIP6, modulates the interaction of PICK1 with GluR6 kainate receptors.
18690046 Functional consequences of natural substitutions in the GluR6 kainate receptor subunit ligand-binding site.
18664604 2008 Mutations to the kainate receptor subunit GluR6 binding pocket that selectively affect domoate binding.
18658129 2008 Luminescence resonance energy transfer investigation of conformational changes in the ligand binding domain of a kainate receptor.
18593792 2008 Genetic markers within glutamate receptors associated with antidepressant treatment-emergent suicidal ideation.
18519826 2008 Molecular genetics of successful smoking cessation: convergent genome-wide association study results.
18289788 2008 Human GluR6c, a functional splicing variants of GluR6, is mainly expressed in non-nervous cells.
17847003 2007 A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation.
17712621 2007 Glutamate receptor 6 gene (GluR6 or GRIK2) polymorphisms in the Indian population: a genetic association study on autism spectrum disorder.
17428563 2007 Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios.
17379418 2007 Identification of C-terminal domain residues involved in protein kinase A-mediated potentiation of kainate receptor subtype 6.
17167233 2006 Functional significance of the kainate receptor GluR6(M836I) mutation that is linked to autism.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16959037 2006 Genetic analysis of the GRIK2 modifier effect in Huntington's disease.
16847693 2006 Genetic analysis of candidate genes modifying the age-at-onset in Huntington's disease.
16221857 2005 Q/R site editing controls kainate receptor inhibition by membrane fatty acids.
15537878 2004 Assessing the role of GLUK5 and GLUK6 at hippocampal mossy fiber synapses.
15305151 2004 Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia.
15094479 2004 Frequency and transmission of glutamate receptors GRIK2 and GRIK3 polymorphisms in patients with obsessive compulsive disorder.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14574404 2003 The DNA sequence and analysis of human chromosome 6.
14567698 2003 Channel-opening kinetics of GluR6 kainate receptor.
12954862 2003 Distribution of kainate receptor subunits at hippocampal mossy fiber synapses.
12821179 2003 Modulation of age at onset in Huntington's disease and spinocerebellar ataxia type 2 patients originated from eastern India.
12597860 2003 Rapid and differential regulation of AMPA and kainate receptors at hippocampal mossy fibre synapses by PICK1 and GRIP.
12573530 2003 Heteromer formation of delta2 glutamate receptors with AMPA or kainate receptors.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12467946 2002 Association study of polymorphisms in the GluR6 kainate receptor gene (GRIK2) with schizophrenia.
12151522 2002 Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes.
12070168 2002 Selective binding of synapse-associated protein 97 to GluR-A alpha-amino-5-hydroxy-3-methyl-4-isoxazole propionate receptor subunit is determined by a novel sequence motif.
11744724 2002 The PDZ1 domain of SAP90. Characterization of structure and binding.
11675011 2001 Genomic organization of the human GRIK2 gene and evidence for multiple splicing variants.
11279111 2001 Molecular mechanisms regulating the differential association of kainate receptor subunits with SAP90/PSD-95 and SAP97.
11276111 2001 The introduction of MR in the Nordic countries with special reference to Norway: central control versus local initiatives.
10358037 1999 Subtype-specific assembly of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor subunits is mediated by their n-terminal domains.
9808460 1998 SAP90 binds and clusters kainate receptors causing incomplete desensitization.
9651532 1998 RNA editing of brain glutamate receptor channels: mechanism and physiology.
9466455 1998 Expression and heteromeric interactions of non-N-methyl-D-aspartate glutamate receptor subunits in the developing and adult cerebellum.
9108071 1997 Genotypes at the GluR6 kainate receptor locus are associated with variation in the age of onset of Huntington disease.
9099808 1997 Distribution of kainate receptor subunit mRNAs in human hippocampus, neocortex and cerebellum, and bilateral reduction of hippocampal GluR6 and KA2 transcripts in schizophrenia.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
8618850 1995 Palmitoylation of the GluR6 kainate receptor.
8288598 1994 Biochemical and assembly properties of GluR6 and KA2, two members of the kainate receptor family, determined with subunit-specific antibodies.
8188697 1994 A transmembrane model for an ionotropic glutamate receptor predicted on the basis of the location of asparagine-linked oligosaccharides.
8163463 1994 Transmembrane topology of the glutamate receptor subunit GluR6.
8094892 1993 Phosphorylation and modulation of recombinant GluR6 glutamate receptors by cAMP-dependent protein kinase.
8034316 1994 Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, polymorphism, and chromosomal assignment.
7696618 1994 RNA editing of human kainate receptor subunits.
7675232 1995 Refinement of map position of the human GluR6 kainate receptor gene (GRIK2) and lack of association and linkage with idiopathic generalized epilepsies.
7536611 1994 Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit.
7523595 1994 RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue.