Tbio GREB1 Protein GREB1

Protein Summary

Description

May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers. This gene is an estrogen-responsive gene that is an early response gene in the estrogen receptor-regulated pathway. It is thought to play an important role in hormone-responsive tissues and cancer. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q4ZG55
• A6NHD0
• A6NKN0
• B5MDA9
• O60321
• Q7Z5S2
• Q9H2Q6
• Q9H2Q7
• Q9H2Q8

Gene Name

• GREB1

Ensembl ID

• ENST00000234142
• ENSP00000234142
• ENSG00000196208
• ENST00000263834
• ENSP00000263834
• ENST00000381483
• ENSP00000370892
• ENST00000381486
• ENSP00000370896
• ENST00000396123
• ENSP00000379429

Symbol

• KIAA0575

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.85
gene perturbation	0.76
transcription factor	0.7
microRNA	0.63
small molecule perturbation	0.63

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.18   (req: < 5)

Gene RIFs: 38   (req: <= 3)

Antibodies: 157   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.18   (req: >= 5)

Gene RIFs: 38   (req: > 3)

Antibodies: 157   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0