Property Summary

NCBI Gene PubMed Count 14
PubMed Score 198.84
PubTator Score 60.60

Knowledge Summary


No data available



  Differential Expression (5)

Disease log2 FC p
breast carcinoma -1.300 9.5e-05
atypical teratoid/rhabdoid tumor -1.100 2.1e-05
group 4 medulloblastoma -1.300 3.6e-04
lung adenocarcinoma -3.400 9.1e-16
non-inflammatory breast cancer -1.300 2.9e-03

Gene RIF (7)

26048293 Schizophrenia subjects compared to controls showed a marked increase in CA1 hippocampal Norbin, and Tamalin proteins (47% and 34% respectively), which are endogenous regulators of mGluR5 signalling and trafficking
24505136 myristoylated GRASP promoted tethering and exhibited a unique membrane complex. Thus, myristoylation restricts the membrane orientation of the GRASP domain favoring interactions in trans for membrane tethering.
23441967 GRASP bridges the guanine nucleotide exchange factors (GEFs) that activate Arf and Rac, thereby promoting Arf-to-Rac signaling By binding to both cytohesin 2/ARNO and Dock180.
22931251 GRASP regulates the non-clathrin/Arf6-dependent, plasma membrane recycling and signalling pathways.
22523075 the structural basis of the phosphoinhibition of GRASP-mediated membrane tethering and provide a mechanism for its allosteric regulation.
20016009 protein-protein interaction mediated by ARNO coiled-coil domain required for ARNO induced motility; coiled-coil domain promotes assembly of multiprotein complex containing ARNO and Dock180; assembly of complex requires coiled-coil domain, GRASP and IPCEF
17396155 The crystal structures of the autoinhibitory PDZ domain of Tamalin has implications for the regulation of metabotropic glutamate receptor trafficking.

AA Sequence


Text Mined References (15)

PMID Year Title
26048293 2015 Metabotropic glutamate receptor 5, and its trafficking molecules Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia.
24939585 2015 Genome-wide association analysis demonstrates the highly polygenic character of age-related hearing impairment.
24505136 2014 Myristoylation restricts orientation of the GRASP domain on membranes and promotes membrane tethering.
23441967 2013 The scaffolding protein GRASP/Tamalin directly binds to Dock180 as well as to cytohesins facilitating GTPase crosstalk in epithelial cell migration.
22931251 2012 Grp1-associated scaffold protein (GRASP) is a regulator of the ADP ribosylation factor 6 (Arf6)-dependent membrane trafficking pathway.
22523075 2012 Allosteric regulation of GRASP protein-dependent Golgi membrane tethering by mitotic phosphorylation.
20016009 2010 GRASP and IPCEF promote ARF-to-Rac signaling and cell migration by coordinating the association of ARNO/cytohesin 2 with Dock180.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
17396155 2007 Crystal structures of autoinhibitory PDZ domain of Tamalin: implications for metabotropic glutamate receptor trafficking regulation.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
12586822 2003 Tamalin is a scaffold protein that interacts with multiple neuronal proteins in distinct modes of protein-protein association.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11850456 2002 Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.
10828067 2000 Interaction of GRASP, a protein encoded by a novel retinoic acid-induced gene, with members of the cytohesin family of guanine nucleotide exchange factors.
9828130 1998 Cloning of ARE-containing genes by AU-motif-directed display.