| Tbio | Glutathione peroxidase 2 |
Could play a major role in protecting mammals from the toxicity of ingested organic hydroperoxides. Tert-butyl hydroperoxide, cumene hydroperoxide and linoleic acid hydroperoxide but not phosphatidycholine hydroperoxide, can act as acceptors.
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage. Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate specificity. This isozyme is predominantly expressed in the gastrointestinal tract (also in liver in human), is localized in the cytoplasm, and whose preferred substrate is hydrogen peroxide. Overexpression of this gene is associated with increased differentiation and proliferation in colorectal cancer. This isozyme is also a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Breast Neoplasms | 445 | 0.0 | 0.0 |
| Liver neoplasms | 130 | 0.0 | 0.0 |
| Neoplasm Metastasis | 168 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Mammary Neoplasms | 425 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.8e-20 |
| non-small cell lung cancer | 2890 | 3.0e-15 |
| osteosarcoma | 7950 | 8.5e-08 |
| lung cancer | 4740 | 1.4e-07 |
| pancreatic cancer | 2398 | 5.2e-06 |
| lung adenocarcinoma | 2716 | 3.0e-05 |
| psoriasis | 6694 | 3.3e-05 |
| primary pancreatic ductal adenocarcinoma | 1109 | 9.6e-04 |
| head and neck cancer and chronic obstructive pulmonary disease | 239 | 2.2e-03 |
| inflammatory breast cancer | 286 | 7.9e-03 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 8.0e-03 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 1.3e-02 |
| primary Sjogren syndrome | 735 | 1.4e-02 |
| cystic fibrosis | 1696 | 1.4e-02 |
| esophageal adenocarcinoma | 737 | 1.8e-02 |
| colon cancer | 1478 | 1.9e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 4.4e-02 |
| interstitial cystitis | 2312 | 4.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| colon cancer | 1.500 | 1.9e-02 |
| cystic fibrosis | -1.500 | 1.4e-02 |
| esophageal adenocarcinoma | 1.900 | 1.8e-02 |
| head and neck cancer and chronic obstruc... | -1.600 | 2.2e-03 |
| inflammatory breast cancer | -1.100 | 7.9e-03 |
| interstitial cystitis | -2.500 | 4.7e-02 |
| intraductal papillary-mucinous adenoma (... | 2.200 | 8.0e-03 |
| intraductal papillary-mucinous carcinoma... | 2.300 | 1.3e-02 |
| intraductal papillary-mucinous neoplasm ... | 2.300 | 4.4e-02 |
| lung adenocarcinoma | 1.900 | 3.0e-05 |
| lung cancer | 6.100 | 1.4e-07 |
| lung carcinoma | 2.400 | 1.8e-20 |
| non-small cell lung cancer | 4.293 | 3.0e-15 |
| osteosarcoma | 2.393 | 8.5e-08 |
| pancreatic cancer | 2.400 | 5.2e-06 |
| primary pancreatic ductal adenocarcinoma | 3.264 | 9.6e-04 |
| primary Sjogren syndrome | -1.200 | 1.4e-02 |
| psoriasis | 1.200 | 3.3e-05 |
