| Tbio | G-protein coupled receptor-associated sorting protein 2 |
May play a role in regulation of a variety of G-protein coupled receptors.
The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 muscarinic acetylcholine receptor and the calcitonin receptor. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
The protein encoded by this gene is a member of a family that regulates the activity of G protein-coupled receptors (GPCRs). The encoded protein has been shown to be capable of interacting with several GPCRs, including the M1 muscarinic acetylcholine receptor and the calcitonin receptor. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, May 2010]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 1.4e-31 |
| breast carcinoma | 1638 | 1.8e-28 |
| Breast cancer | 3578 | 4.5e-15 |
| ovarian cancer | 8520 | 4.9e-13 |
| glioblastoma | 5792 | 3.0e-06 |
| medulloblastoma, large-cell | 6241 | 7.6e-05 |
| adult high grade glioma | 3801 | 9.1e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.3e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 4.9e-04 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.0e-03 |
| invasive ductal carcinoma | 2951 | 1.2e-03 |
| interstitial cystitis | 2312 | 1.2e-03 |
| astrocytic glioma | 2597 | 4.3e-03 |
| ependymoma | 4679 | 7.5e-03 |
| subependymal giant cell astrocytoma | 2287 | 1.1e-02 |
| Pick disease | 1894 | 1.5e-02 |
| oligodendroglioma | 2850 | 2.6e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.500 | 9.1e-05 |
| astrocytic glioma | -2.200 | 4.3e-03 |
| atypical teratoid / rhabdoid tumor | -1.500 | 1.3e-04 |
| Breast cancer | -1.700 | 4.5e-15 |
| breast carcinoma | -1.200 | 1.8e-28 |
| ependymoma | -3.000 | 7.5e-03 |
| glioblastoma | -1.100 | 3.0e-06 |
| interstitial cystitis | -1.100 | 1.2e-03 |
| intraductal papillary-mucinous carcinoma... | -1.700 | 4.9e-04 |
| intraductal papillary-mucinous neoplasm ... | -1.800 | 1.0e-03 |
| invasive ductal carcinoma | -1.235 | 1.2e-03 |
| lung carcinoma | 1.900 | 1.4e-31 |
| medulloblastoma, large-cell | -1.900 | 7.6e-05 |
| oligodendroglioma | -1.600 | 2.6e-02 |
| ovarian cancer | -3.500 | 4.9e-13 |
| Pick disease | -1.400 | 1.5e-02 |
| subependymal giant cell astrocytoma | -1.621 | 1.1e-02 |
MTGAEIEPSAQAKPEKKAGEEVIAGPERENDVPLVVRPKVRTQATTGARPKTETKSVPAARPKTEAQAMS 1 - 70 GARPKTEVQVMGGARPKTEAQGITGARPKTDARAVGGARSKTDAKAIPGARPKDEAQAWAQSEFGTEAVS 71 - 140 QAEGVSQTNAVAWPLATAESGSVTKSKGLSMDRELVNVDAETFPGTQGQKGIQPWFGPGEETNMGSWCYS 141 - 210 RPRAREEASNESGFWSADETSTASSFWTGEETSVRSWPREESNTRSRHRAKHQTNPRSRPRSKQEAYVDS 211 - 280 WSGSEDEASNPFSFWVGENTNNLFRPRVREEANIRSKLRTNREDCFESESEDEFYKQSWVLPGEEANSRF 281 - 350 RHRDKEDPNTALKLRAQKDVDSDRVKQEPRFEEEVIIGSWFWAEKEASLEGGASAICESEPGTEEGAIGG 351 - 420 SAYWAEEKSSLGAVAREEAKPESEEEAIFGSWFWDRDEACFDLNPCPVYKVSDRFRDAAEELNASSRPQT 421 - 490 WDEVTVEFKPGLFHGVGFRSTSPFGIPEEASEMLEAKPKNLELSPEGEEQESLLQPDQPSPEFTFQYDPS 491 - 560 YRSVREIREHLRARESAESESWSCSCIQCELKIGSEEFEEFLLLMDKIRDPFIHEISKIAMGMRSASQFT 561 - 630 RDFIRDSGVVSLIETLLNYPSSRVRTSFLENMIHMAPPYPNLNMIETFICQVCEETLAHSVDSLEQLTGI 631 - 700 RMLRHLTMTIDYHTLIANYMSGFLSLLTTANARTKFHVLKMLLNLSENPAVAKKLFSAKALSIFVGLFNI 701 - 770 EETNDNIQIVIKMFQNISNIIKSGKMSLIDDDFSLEPLISAFREFEELAKQLQAQIDNQNDPEVGQQS 771 - 838 //
