Property Summary

NCBI Gene PubMed Count 21
PubMed Score 43.80
PubTator Score 30.90

Knowledge Summary

Patent (8,390)

Expression

  Differential Expression (11)

Disease log2 FC p
psoriasis -2.200 2.3e-05
osteosarcoma -3.000 1.1e-07
medulloblastoma, large-cell -1.200 3.6e-05
intraductal papillary-mucinous adenoma (... -1.500 1.2e-03
intraductal papillary-mucinous carcinoma... -1.400 2.1e-03
intraductal papillary-mucinous neoplasm ... -1.400 2.3e-02
lung cancer -1.800 4.1e-04
interstitial cystitis 1.300 1.3e-04
lung adenocarcinoma -1.300 1.7e-06
ovarian cancer 1.300 3.5e-09
facioscapulohumeral dystrophy 1.900 2.9e-02

Gene RIF (13)

PMID Text
27078157 GPR4 induces angiogenesis via GPR4-induced p38-mediated IL6, IL8 and VEGFA secretion at acidic extracellular pH in squamous cell carcinoma of the head and neck
23888957 The results suggested that GPR4 may play an important role in the development of epithelial ovarian carcinoma (EOC), and its overexpression might be required for the angiogenesis, tumor growth, and metastasis of EOC
22110680 acidosis/GPR4 signaling regulates endothelial cell adhesion mainly through the G(s)/cAMP/Epac pathway
20211729 The mutation of histidine residue at 79, 165, or 269 from the N-terminal of GPR4 to phenylalanine shifted the half-maximal effective concentration (EC(50)) of proton-induced signaling activities to the right, including cAMP accumulation.
17462861 Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.
17437524 lysophosphatidylcholine receptor G protein-coupled receptor 4 (GPK4) was expressed in YPEN-1 cells and triggered the cAMP/protein kinase A/cAMP response element-binding protein pathway, resulting in upregulation of adhesion molecules.
17364894 GPR4 in brain endothelial cells regulates monocyte transmigration.
16461426 GPR4 may play a critical role in the inflammatory responses activated by lysophosphatidylcholine
15857892 results identify sphingosylphosphorylcholine and its receptor, G protein-coupled receptor 4(GPR4), as critical regulators of the angiogenic potential of endothelial cells
15221007 GPR4 and TDAG8 overexpression in human tumors plays a role in driving or maintaining tumor formation
14567679 sphingosylphosphorylcholine and lysophosphatidic acid are not the ligands for GPR4 and that this receptor may constitutively inhibit ERK1/2 activation
12955148 GPR4, a close relative of OGR1, also responds to pH changes, but elicits cyclic AMP formation
12805023 Endogenous GPR4 in endothelial cells may be a potential G protein-coupled receptor by which LPC signals proinflammatory activities.

AA Sequence

MGNHTWEGCHVDSRVDHLFPPSLYIFVIGVGLPTNCLALWAAYRQVQQRNELGVYLMNLSIADLLYICTL      1 - 70
PLWVDYFLHHDNWIHGPGSCKLFGFIFYTNIYISIAFLCCISVDRYLAVAHPLRFARLRRVKTAVAVSSV     71 - 140
VWATELGANSAPLFHDELFRDRYNHTFCFEKFPMEGWVAWMNLYRVFVGFLFPWALMLLSYRGILRAVRG    141 - 210
SVSTERQEKAKIKRLALSLIAIVLVCFAPYHVLLLSRSAIYLGRPWDCGFEERVFSAYHSSLAFTSLNCV    211 - 280
ADPILYCLVNEGARSDVAKALHNLLRFLASDKPQEMANASLTLETPLTSKRNSTAKAMTGSWAATPPSQG    281 - 350
DQVQLKMLPPAQ                                                              351 - 362
//

Text Mined References (24)

PMID Year Title
27078157 2016 The Proton-Sensing G-Protein Coupled Receptor GPR4 Promotes Angiogenesis in Head and Neck Cancer.
23888957 2014 Relations between GPR4 expression, microvascular density (MVD) and clinical pathological characteristics of patients with epithelial ovarian carcinoma (EOC).
22110680 2011 Activation of GPR4 by acidosis increases endothelial cell adhesion through the cAMP/Epac pathway.
20211729 2010 Each one of certain histidine residues in G-protein-coupled receptor GPR4 is critical for extracellular proton-induced stimulation of multiple G-protein-signaling pathways.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17462861 2007 Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms.
17437524 2007 Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4.
17364894 A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration.
16754659 2006 Stable association between G alpha(q) and phospholipase C beta 1 in living cells.
16461426 2006 Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15857892 2005 GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15221007 2004 G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers.
15057824 2004 The DNA sequence and biology of human chromosome 19.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14567679 2003 The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner.
12955148 2003 Proton-sensing G-protein-coupled receptors.
12805023 2003 Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11535583 2001 Sphingosylphosphorylcholine and lysophosphatidylcholine are ligands for the G protein-coupled receptor GPR4.
8595909 1995 Isolation of a novel G protein-coupled receptor (GPR4) localized to chromosome 19q13.3.
7832990 1995 Isolation of three novel human genes encoding G protein-coupled receptors.
7498459 1995 Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue.