Tdark GPR25 Probable G-protein coupled receptor 25

Protein Summary

Description

Orphan receptor. This gene is intronless and encodes a member of the G-protein coupled receptor 1 family. G-protein coupled receptors are membrane proteins which activate signaling cascades as a response to extracellular stress. This gene has been linked to arterial stiffness. [provided by RefSeq, Nov 2012]

Uniprot Accession IDs

• O00155
• A0AVJ5

Gene Name

• GPR25

Ensembl ID

• ENST00000304244
• ENSP00000301917
• ENSG00000170128

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell type or tissue	0.6
gene perturbation	0.47
cell line	0.46
tissue sample	0.46
protein complex	0.4

Protein Classes

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Angiotensin Receptor / Probable G-protein Coupled Receptor 25

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 166   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.11   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 166   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0