Tbio GPR12 G-protein coupled receptor 12

Protein Summary

Description

Promotes neurite outgrowth and blocks myelin inhibition in neurons (By similarity). Receptor with constitutive G(s) signaling activity that stimulates cyclic AMP production.

Uniprot Accession IDs

• P47775
• Q5T8P3

Gene Name

• GPR12

Ensembl ID

• ENST00000381436
• ENSP00000370844
• ENSG00000132975
• ENST00000405846
• ENSP00000384932

Symbol

• GPCR12
• GPCR21
• PPP1R84

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.95
microRNA	0.78
cell type or tissue	0.76
molecular function	0.63
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / G-protein Coupled Receptor 12

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / G-protein Coupled Receptor 12

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.33   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 276   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.33   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0