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Tbio
GPM6A
Neuronal membrane glycoprotein M6-a

Protein Summary
Description
Involved in neuronal differentiation, including differentiation and migration of neuronal stem cells. Plays a role in neuronal plasticity and is involved in neurite and filopodia outgrowth, filopodia motility and probably synapse formation. GPM6A-induced filopodia formation involves mitogen-activated protein kinase (MAPK) and Src signaling pathways. May be involved in neuronal NGF-dependent Ca(2+) influx. May be involved in regulation of endocytosis and intracellular trafficking of G-protein-coupled receptors (GPCRs); enhances internalization and recycling of mu-type opioid receptor.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280187
  • ENSP00000280187
  • ENSG00000150625
  • ENST00000393658
  • ENSP00000377268
  • ENST00000506894
  • ENSP00000421578
  • ENST00000515090
  • ENSP00000423984

Symbol
  • M6A
  • M6A
  • GPM6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
gene perturbation
0.88
transcription factor perturbation
0.88
PubMedID
0.82
transcription factor
0.69


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.92   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 43.92   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0