| Tbio | Glycerol-3-phosphate acyltransferase 4 |
Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipid biosynthesis. Active against both saturated and unsaturated long-chain fatty acyl-CoAs.
Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
Lysophosphatidic acid acyltransferases (EC 2.3.1.51) catalyze the conversion of lysophosphatidic acid (LPA) to phosphatidic acid (PA). LPA and PA are involved in signal transduction and lipid biosynthesis.[supplied by OMIM, Apr 2004]
Comments
| PMID | Text | |
|---|---|---|
| 24156295 | None of the eleven AGPAT6 variants were robustly associated with type 2 diabetes in the Danish. | |
| 20181984 | Results reveal a link between the lipogenic effects of insulin and microsomal GPAT3 and GPAT4, implying their importance in glycerolipid biosynthesis. | |
| 18238778 | AGPAT6 is a microsomal GPAT, and we propose renaming this enzyme GPAT4. | |
| 16625827 | we have cloned a novel human gene and this gene may play an important role in human spermatogenesis and sexual maturation. |
MFLLLPFDSLIVNLLGISLTVLFTLLLVFIIVPAIFGVSFGIRKLYMKSLLKIFAWATLRMERGAKEKNH 1 - 70 QLYKPYTNGIIAKDPTSLEEEIKEIRRSGSSKALDNTPEFELSDIFYFCRKGMETIMDDEVTKRFSAEEL 71 - 140 ESWNLLSRTNYNFQYISLRLTVLWGLGVLIRYCFLLPLRIALAFTGISLLVVGTTVVGYLPNGRFKEFMS 141 - 210 KHVHLMCYRICVRALTAIITYHDRENRPRNGGICVANHTSPIDVIILASDGYYAMVGQVHGGLMGVIQRA 211 - 280 MVKACPHVWFERSEVKDRHLVAKRLTEHVQDKSKLPILIFPEGTCINNTSVMMFKKGSFEIGATVYPVAI 281 - 350 KYDPQFGDAFWNSSKYGMVTYLLRMMTSWAIVCSVWYLPPMTREADEDAVQFANRVKSAIARQGGLVDLL 351 - 420 WDGGLKREKVKDTFKEEQQKLYSKMIVGNHKDRSRS 421 - 456 //
| PMID | Year | Title | |
|---|---|---|---|
| 25918168 | 2015 | Glycerol-3-phosphate Acyltransferase Isoform-4 (GPAT4) Limits Oxidation of Exogenous Fatty Acids in Brown Adipocytes. | |
| 24156295 | 2013 | Studies of association of AGPAT6 variants with type 2 diabetes and related metabolic phenotypes in 12,068 Danes. | |
| 20181984 | 2010 | GPAT3 and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis. | |
| 19946888 | 2010 | Defining the membrane proteome of NK cells. | |
| 18238778 | 2008 | AGPAT6 is a novel microsomal glycerol-3-phosphate acyltransferase. | |
| 16713569 | 2006 | A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. | |
| 16625827 | 2006 | Molecular cloning and preliminary function study of a novel human gene, TSARG7, related to spermatogenesis. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 12975309 | 2003 | The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. | |
| 12938015 | 2003 | Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 8944226 | 1996 | Biosynthesis of triacylglycerols. |
