Tbio GORAB RAB6-interacting golgin

Protein Summary

Description

This gene encodes a member of the golgin family, a group of coiled-coil proteins localized to the Golgi. The encoded protein may function in the secretory pathway. The encoded protein, which also localizes to the cytoplasm, was identified by interactions with the N-terminal kinase-like protein, and thus it may function in mitosis. Mutations in this gene have been associated with geroderma osteodysplastica. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• Q5T7V8
• Q49A22
• Q6P1P9
• Q9HAE6
• Q9Y350

Gene Name

• GORAB

Ensembl ID

• ENST00000367762
• ENSP00000356736
• ENSG00000120370
• ENST00000367763
• ENSP00000356737

Symbol

• NTKLBP1
• SCYL1BP1
• GO
• NTKLBP1
• SCYL1BP1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.85
microRNA	0.8
cell type or tissue	0.79
transcription factor	0.74
transcription factor binding site profile	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.79   (req: < 5)

Gene RIFs: 12   (req: <= 3)

Antibodies: 321   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.79   (req: >= 5)

Gene RIFs: 12   (req: > 3)

Antibodies: 321   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0