Tclin GNRHR Gonadotropin-releasing hormone receptor

Protein Summary

Description

Receptor for gonadotropin releasing hormone (GnRH) that mediates the action of GnRH to stimulate the secretion of the gonadotropic hormones luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This receptor mediates its action by association with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Isoform 2 may act as an inhibitor of GnRH-R signaling. This gene encodes the receptor for type 1 gonadotropin-releasing hormone. This receptor is a member of the seven-transmembrane, G-protein coupled receptor (GPCR) family. It is expressed on the surface of pituitary gonadotrope cells as well as lymphocytes, breast, ovary, and prostate. Following binding of gonadotropin-releasing hormone, the receptor associates with G-proteins that activate a phosphatidylinositol-calcium second messenger system. Activation of the receptor ultimately causes the release of gonadotropic luteinizing hormone (LH) and follicle stimulating hormone (FSH). Defects in this gene are a cause of hypogonadotropic hypogonadism (HH). Alternative splicing results in multiple transcript variants encoding different isoforms. More than 18 transcription initiation sites in the 5' region and multiple polyA signals in the 3' region have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P30968
• O75793
• Q14D13
• Q92644
• GnRH receptor

Gene Name

• GNRHR

Ensembl ID

• ENST00000226413
• ENSP00000226413
• ENSG00000109163
• ENST00000420975
• ENSP00000397561

Symbol

• GRHR
• HH7
• GRHR
• LRHR
• LHRHR
• GNRHR1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
ligand (chemical)	0.97
biological term	0.82
cell type or tissue	0.7
trait	0.61
drug	0.6

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / Gonadotropin-releasing Hormone Receptor

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Gonadotrophin-releasing Hormone Receptor / Gonadotropin-releasing Hormone Receptor

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.71   (req: < 5)

Gene RIFs: 118   (req: <= 3)

Antibodies: 393   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 588.71   (req: >= 5)

Gene RIFs: 118   (req: > 3)

Antibodies: 393   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 986

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 13