Tdark GNG14 Putative guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-14

Protein Summary

Description

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Uniprot Accession IDs

• A0A1W2PPG7

Gene Name

• GNG14

Ensembl ID

• ENST00000640117
• ENSP00000491535
• ENSG00000283980

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Putative Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-14

DTO Classes

Protein / Enzyme Modulator / G-protein / Heterotrimeric G-protein / Putative Guanine Nucleotide-binding Protein G(i)/g(s)/g(o) Subunit Gamma-14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 0   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0