Property Summary

NCBI Gene PubMed Count 12
PubMed Score 0.71
PubTator Score 3.43

Knowledge Summary


No data available


  Disease (2)

Disease Target Count
Adenocarcinoma 115
Stomach Neoplasms 282
Disease Target Count P-value
Multiple myeloma 1327 2.0e-03
ovarian cancer 8491 8.7e-03


  Differential Expression (2)

Disease log2 FC p
Multiple myeloma 1.118 2.0e-03
ovarian cancer 1.600 8.7e-03

Gene RIF (5)

23208589 Loss of expression of GMPR2 and PPARalpha is associated with breast cancer basal phenotype; indicating that they may play a role in carcinogenesis.
22037469 A single crystal structure of human GMPR type 2 with IMP and NADPH fortuitously captures three different states, each of which mimics a distinct step in the catalytic cycle of guanosine monophosphate reductase(GMPR).
21048031 Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator)
12669231 GMPR2 is a novel human GMP reductase, and overexpression of GMPR2 can promote the monocytic differentiation of HL-60 leukemia cells.
12009299 Data suggest the existence of two distinct types of human GMP reductase molecular species, which can be used to explain the bimodal saturation curve noted with purified human erythrocyte GMP reductase.

AA Sequence


Text Mined References (17)

PMID Year Title
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23208589 2013 Lack of expression of the proteins GMPR2 and PPAR? are associated with the basal phenotype and patient outcome in breast cancer.
22037469 2011 Cofactor mobility determines reaction outcome in the IMPDH and GMPR (?-?)8 barrel enzymes.
21269460 2011 Initial characterization of the human central proteome.
21048031 2011 Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph.
19608861 2009 Lysine acetylation targets protein complexes and co-regulates major cellular functions.
17207965 2007 hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes.
16359702 2006 Crystal structure of human guanosine monophosphate reductase 2 (GMPR2) in complex with GMP.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15342556 2004 Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions.
12669231 2003 Cloning and functional characterization of GMPR2, a novel human guanosine monophosphate reductase, which promotes the monocytic differentiation of HL-60 leukemia cells.
12508121 2003 The DNA sequence and analysis of human chromosome 14.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12009299 2002 NADPH-dependent GMP reductase isoenzyme of human (GMPR2). Expression, purification, and kinetic properties.
11752456 2001 Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver.
10737800 2000 Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.
218932 1979 Reaction mechanism and specificity of human GMP reductase. Substrates, inhibitors, activators, and inactivators.