Tbio GMPR2 GMP reductase 2

Protein Summary

Description

Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides (PubMed:12009299, PubMed:12669231, PubMed:16359702, PubMed:22037469). Plays a role in modulating cellular differentiation (PubMed:12669231). This gene encodes an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of guanosine monophosphate (GMP) to inosine monophosphate (IMP). The protein also functions in the re-utilization of free intracellular bases and purine nucleosides. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017]

Uniprot Accession IDs

• Q9P2T1
• D3DS66
• Q567T0
• Q6IAJ8
• Q86T14
• GMPR 2

Gene Name

• GMPR2

Ensembl ID

• ENST00000355299
• ENSP00000347449
• ENSG00000100938
• ENST00000399440
• ENSP00000382369
• ENST00000420554
• ENSP00000392859
• ENST00000456667
• ENSP00000405743
• ENST00000559836
• ENSP00000453299
• ENST00000642276
• ENSP00000496504
• ENSG00000284752
• ENST00000643803
• ENSP00000495708
• ENST00000644066
• ENSP00000494224
• ENST00000645781
• ENSP00000496234
• ENST00000647320
• ENSP00000495583

Symbol

• GMPR 2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.82
kinase perturbation	0.81
transcription factor	0.67
transcription factor binding site profile	0.67
tissue sample	0.65

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.5   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 108   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.5   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 108   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0