Tclin | Glycine receptor subunit alpha-1 |
The protein encoded by this gene is a subunit of a pentameric inhibitory glycine receptor, which mediates postsynaptic inhibition in the central nervous system. Defects in this gene are a cause of startle disease (STHE), also known as hereditary hyperekplexia or congenital stiff-person syndrome. Multiple transcript variants encoding different isoforms have been found. [provided by RefSeq, Dec 2015]
Comments
Property Summary
Ligand Count | 45 |
NCBI Gene PubMed Count | 127 |
PubMed Score | 119.03 |
PubTator Score | 139.16 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Dystonic Disorders | 7 | 0.0 | 0.0 |
Hyperexplexia hereditary | 4 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
General anesthesia | 53 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Hyperekplexia | 16 | 8.394 | 4.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Periodic limb movement disorder | 5 | 4.578 | 2.3 |
Schizotypal personality disorder | 7 | 3.34 | 1.7 |
Aspiration Pneumonia | 4 | 3.053 | 1.5 |
Disease | Target Count |
---|---|
Hyperekplexia, Hereditary 1 | 4 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA | ||
Inparanoid OMA |
telmisartan
pEC50 5.50
regorafenib
pEC50 5.75
dronabinol
pEC50 5.89
adapalene
pEC50 5.89
colecalciferol
pEC50 6.40
sulindac
pEC50 6.42
dutasteride
pEC50 6.48
cinacalcet
pEC50 6.50
CHEMBL221823
pIC50 5.00
CHEMBL388075
pIC50 5.05
CHEMBL2398352
pIC50 5.06
CHEMBL374004
pIC50 5.10
CHEMBL221715
pIC50 5.10
CHEMBL426556
pIC50 5.10
CHEMBL376289
pIC50 5.10
CHEMBL373969
pIC50 5.20
CHEMBL221821
pIC50 5.23
CHEMBL296419
pEC50 5.38
CHEMBL465161
pIC50 5.42
CHEMBL514432
pIC50 5.50
CHEMBL416956
pEC50 5.60
CHEMBL1423
pEC50 5.77
CHEMBL46516
pEC50 5.92
CHEMBL2113267
pIC50 6.10
CHEMBL85
pEC50 6.50

Zn2+
pIC50 4.80
MYSFNTLRLYLWETIVFFSLAASKEAEAARSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCN 1 - 70 IFINSFGSIAETTMDYRVNIFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEIT 71 - 140 TDNKLLRISRNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQEQGAVQVADGL 141 - 210 TLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWISFWINMDAAPAR 211 - 280 VGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLEYAAVNFVSRQHKELLRFRRKRR 281 - 350 HHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAKDGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRA 351 - 420 KKIDKISRIGFPMAFLIFNMFYWIIYKIVRREDVHNQ 421 - 457 //