| Tchem | Zinc finger protein GLI1 |
Isoform 2: Acts as a transcriptional activator, but activates a different set of genes than isoform 1. Activates expression of CD24, unlike isoform 1. Mediates SHH signaling. Promotes cancer cell migration.
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
This gene encodes a member of the Kruppel family of zinc finger proteins. The encoded transcription factor is activated by the sonic hedgehog signal transduction cascade and regulates stem cell proliferation. The activity and nuclear localization of this protein is negatively regulated by p53 in an inhibitory loop. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Comments
Property Summary
| Ligand Count | 2 |
| NCBI Gene PubMed Count | 294 |
| PubMed Score | 1054.80 |
| PubTator Score | 616.22 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Carcinoma, Hepatocellular | 228 | 0.0 | 0.0 |
| Gastrointestinal Stromal Tumors | 48 | 0.0 | 0.0 |
| Leukemia, Promyelocytic, Acute | 36 | 0.0 | 0.0 |
| Lymphoma, Large B-Cell, Diffuse | 34 | 0.0 | 0.0 |
| Peripheral Nervous System Diseases | 52 | 0.0 | 0.0 |
| Urinary Bladder Neoplasms | 114 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 3.5e-27 |
| malignant mesothelioma | 3232 | 1.5e-05 |
| sonic hedgehog group medulloblastoma | 467 | 6.7e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 5.6e-04 |
| osteosarcoma | 7950 | 1.5e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Nevoid basal cell carcinoma syndrome | 16 | 4.736 | 2.4 |
| Polydactyly | 107 | 3.921 | 2.0 |
| Holoprosencephaly | 56 | 3.16 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 1.200 | 5.6e-04 |
| malignant mesothelioma | 1.300 | 1.5e-05 |
| osteosarcoma | 1.720 | 1.5e-03 |
| psoriasis | -1.100 | 3.5e-27 |
| sonic hedgehog group medulloblastoma | 1.500 | 6.7e-05 |
MFNSMTPPPISSYGEPCCLRPLPSQGAPSVGTEGLSGPPFCHQANLMSGPHSYGPARETNSCTEGPLFSS 1 - 70 PRSAVKLTKKRALSISPLSDASLDLQTVIRTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPAQMN 71 - 140 HQKGPSPSFGVQPCGPHDSARGGMIPHPQSRGPFPTCQLKSELDMLVGKCREEPLEGDMSSPNSTGIQDP 141 - 210 LLGMLDGREDLEREEKREPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWGGCSRELR 211 - 280 PFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPYMCEHEGCSKAFSNASDRAK 281 - 350 HQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGPDAHVTKRHRGDGPLPRAPSISTVEPKREREG 351 - 420 GPIREESRLTVPEGAMKPQPSPGAQSSCSSDHSPAGSAANTDSGVEMTGNAGGSTEDLSSLDEGPCIAGT 421 - 490 GLSTLRRLENLRLDQLHQLRPIGTRGLKLPSLSHTGTTVSRRVGPPVSLERRSSSSSSISSAYTVSRRSS 491 - 560 LASPFPPGSPPENGASSLPGLMPAQHYLLRARYASARGGGTSPTAASSLDRIGGLPMPPWRSRAEYPGYN 561 - 630 PNAGVTRRASDPAQAADRPAPARVQRFKSLGCVHTPPTVAGGGQNFDPYLPTSVYSPQPPSITENAAMDA 631 - 700 RGLQEEPEVGTSMVGSGLNPYMDFPPTDTLGYGGPEGAAAEPYGARGPGSLPLGPGPPTNYGPNPCPQQA 701 - 770 SYPDPTQETWGEFPSHSGLYPGPKALGGTYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEG 771 - 840 PPHPQPLFSHYPQPSPPQYLQSGPYTQPPPDYLPSEPRPCLDFDSPTHSTGQLKAQLVCNYVQSQQELLW 841 - 910 EGGGREDAPAQEPSYQSPKFLGGSQVSPSRAKAPVNTYGPGFGPNLPNHKSGSYPTPSPCHENFVVGANR 911 - 980 ASHRAAAPPRLLPPLPTCYGPLKVGGTNPSCGHPEVGRLGGGPALYPPPEGQVCNPLDSLDLDNTQLDFV 981 - 1050 AILDEPQGLSPPPSHDQRGSSGHTPPPSGPPNMAVGNMSVLLRSLPGETEFLNSSA 1051 - 1106 //
