1. Home
  2. Targets
  3. cell junction protein
  4. gap junction
  5. Gap junction gamma-1 protein

Tbio Gap junction gamma-1 protein

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 34
PubMed Score 186.19
PubTator Score 75.74

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Hypertension 396 0.0 0.0
Disease Target Count
Hypertensive disease 292
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.6
Disease Target Count Z-score Confidence
Heart disease 306 4.339 2.2
Oculodentodigital dysplasia 14 3.795 1.9

Expression

  Differential Expression (26)

Disease log2 FC p
adrenocortical carcinoma 2.846 1.2e-06
adult high grade glioma 1.100 7.1e-03
astrocytic glioma -1.400 3.1e-02
atypical teratoid / rhabdoid tumor 1.500 6.3e-08
Breast cancer 2.000 3.9e-08
cystic fibrosis and chronic rhinosinusit... 1.181 3.6e-02
ependymoma 1.100 1.1e-05
gastric carcinoma 1.300 2.4e-02
glioblastoma 1.200 3.1e-04
group 3 medulloblastoma 1.300 5.2e-03
interstitial cystitis 1.100 8.4e-03
intraductal papillary-mucinous adenoma (... -2.700 2.3e-05
intraductal papillary-mucinous carcinoma... -2.700 4.3e-05
intraductal papillary-mucinous neoplasm ... -2.700 9.8e-04
invasive ductal carcinoma -1.200 1.0e-02
juvenile dermatomyositis 1.246 3.2e-10
lung cancer -3.700 4.8e-06
malignant mesothelioma 1.800 2.0e-07
medulloblastoma, large-cell 1.600 1.0e-05
osteosarcoma 2.387 2.7e-04
ovarian cancer 1.100 8.6e-10
pituitary cancer 1.900 2.3e-03
primitive neuroectodermal tumor 1.200 1.6e-03
subependymal giant cell astrocytoma -2.219 1.9e-02
ulcerative colitis 1.200 5.4e-03
urothelial carcinoma 2.400 3.0e-02

Synonym

Accession P36383 B3KW68 Q4VAY0
Symbols CX45
GJA7

Gene

GJC1

PANTHER Protein Class (2)

  Ortholog (12)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (9)

 GO Function (3)

 GO Component (6)

 GO Process (12)

See all...

 Compartment GO Term (35)

See all...

 IMPC Phenotype (4)

 MGI Phenotype (10)

 HCA RNA Cell Line (56)

See all...

Pathway (9)

Protein-protein Interaction (1)

EXTL2  

PDB (1)

Gene RIF (20)

AA Sequence 

MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAP      1 - 70
LSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDNEEDPMM     71 - 140
YPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCS    141 - 210
RLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFT    211 - 280
WNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLD    281 - 350
LAVQAYSHQNNPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI                            351 - 396
//

Text Mined References (35)

PMID Year Title