GJC1
Gap junction gamma-1 protein
Protein Summary
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]
- ENST00000330514
- ENSP00000333193
- ENSG00000182963
- ENST00000426548
- ENSP00000411528
- ENST00000590758
- ENSP00000466339
- ENST00000592524
- ENSP00000467201
- GJA7
- CX45
- GJA7
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 0.74 | ||
protein domain | 0.73 | ||
PubMedID | 0.71 | ||
transcription factor binding site profile | 0.69 | ||
cellular component | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 261.95 (req: < 5)
Gene RIFs: 27 (req: <= 3)
Antibodies: 319 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 261.95 (req: >= 5)
Gene RIFs: 27 (req: > 3)
Antibodies: 319 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 14
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0