You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
GJB6
Gap junction beta-6 protein

Protein Summary
Description
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Gap junctions allow the transport of ions and metabolites between the cytoplasm of adjacent cells. They are formed by two hemichannels, made up of six connexin proteins assembled in groups. Each connexin protein has four transmembrane segments, two extracellular loops, a cytoplasmic loop formed between the two inner transmembrane segments, and the N- and C-terminus both being in the cytoplasm. The specificity of the gap junction is determined by which connexin proteins comprise the hemichannel. In the past, connexin protein names were based on their molecular weight, however the new nomenclature uses sequential numbers based on which form (alpha or beta) of the gap junction is present. This gene encodes one of the connexin proteins. Mutations in this gene have been found in some forms of deafness and in s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241124
  • ENSP00000241124
  • ENSG00000121742
  • ENST00000356192
  • ENSP00000348521
  • ENST00000400065
  • ENSP00000382938
  • ENST00000400066
  • ENSP00000382939
  • ENST00000636852
  • ENSP00000489698
  • ENST00000643121
  • ENSP00000494468
  • ENST00000643211
  • ENSP00000495841
  • ENST00000644283
  • ENSP00000495320
  • ENST00000644667
  • ENSP00000493621
  • ENST00000647029
  • ENSP00000493834
  • ENST00000647243
  • ENSP00000494733

Symbol
  • ED2
  • EDH
  • HED
  • CX30
  • HED2
  • DFNA3
  • ECTD2
  • DFNA3B
  • DFNB1B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.83
biological term
0.77
phenotype
0.68
disease
0.65
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 923.41   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 227   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 923.41   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 227   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0