Tbio GIT2 ARF GTPase-activating protein GIT2

Protein Summary

Description

GTPase-activating protein for the ADP ribosylation factor family. This gene encodes a member of the GIT protein family, which interact with G protein-coupled receptor kinases and possess ADP-ribosylation factor (ARF) GTPase-activating protein (GAP) activity. GIT proteins traffic between cytoplasmic complexes, focal adhesions, and the cell periphery, and interact with Pak interacting exchange factor beta (PIX) to form large oligomeric complexes that transiently recruit other proteins. GIT proteins regulate cytoskeletal dynamics and participate in receptor internalization and membrane trafficking. This gene has been shown to repress lamellipodial extension and focal adhesion turnover, and is thought to regulate cell motility. This gene undergoes extensive alternative splicing to generate multiple isoforms, but the full-length nature of some of these variants has not been determined. The various isoforms have functional differences, with respect to ARF GAP activity and to G protein-coupled receptor kinase 2 binding. [provided by RefSeq, Sep 2008]

Uniprot Accession IDs

• Q14161
• Q86U59
• Q96CI2
• Q9BV91
• Q9Y5V2
• ARF GAP GIT2

Gene Name

• GIT2

Ensembl ID

• ENST00000355312
• ENSP00000347464
• ENSG00000139436
• ENST00000361006
• ENSP00000354282
• ENST00000457474
• ENSP00000391813
• ENST00000547815
• ENSP00000450348
• ENST00000553118
• ENSP00000447465

Symbol

• KIAA0148
• PKL
• CAT2
• CAT-2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.97
virus perturbation	0.94
disease perturbation	0.87
transcription factor binding site profile	0.78
small molecule perturbation	0.76

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.68   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 273   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 89.68   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 273   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0