Tbio GDI1 Rab GDP dissociation inhibitor alpha

Protein Summary

Description

Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Promotes the dissociation of GDP-bound Rab proteins from the membrane and inhibits their activation. Promotes the dissociation of RAB1A, RAB3A, RAB5A and RAB10 from membranes. GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI1 is expressed primarily in neural and sensory tissues. Mutations in GDI1 have been linked to X-linked nonspecific cognitive disability. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P31150
• P50394
• Q6FG50
• Q7Z2G6
• Q7Z2G9
• Q7Z2H5
• Q7Z2I6
• Rab GDI alpha

Gene Name

• GDI1

Ensembl ID

• ENST00000447750
• ENSP00000394071
• ENSG00000203879

Symbol

• GDIL
• OPHN2
• RABGDIA
• XAP4
• 1A
• GDIL
• MRX41
• MRX48
• OPHN2
• XAP-4
• RABGD1A
• RABGDIA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	0.97
transcription factor perturbation	0.94
kinase perturbation	0.76
interacting protein	0.69
tissue	0.65

Protein Classes

PANTHER Classes

Protein / Transferase / Acyltransferase / Rab Gdp Dissociation Inhibitor Alpha

Protein / Enzyme Modulator / G-protein Modulator / Rab Gdp Dissociation Inhibitor Alpha

DTO Classes

Protein / Enzyme / Transferase / Acyltransferase / Rab Gdp Dissociation Inhibitor Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.39   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 340   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 65.39   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0