Property Summary

NCBI Gene PubMed Count 16
PubMed Score 36.14
PubTator Score 18.87

Knowledge Summary


No data available


  Disease (2)

Disease Target Count P-value
psoriasis 6685 7.4e-41
osteosarcoma 7933 1.3e-05
group 4 medulloblastoma 1875 7.8e-03
chronic lymphocytic leukemia 244 1.1e-02
Disease Target Count Z-score Confidence
Ankylosis 25 3.703 1.9
Barrett's esophagus 185 3.696 1.8


  Differential Expression (4)

Disease log2 FC p
chronic lymphocytic leukemia 1.587 1.1e-02
psoriasis -1.200 7.4e-41
osteosarcoma -2.028 1.3e-05
group 4 medulloblastoma 1.100 7.8e-03

 GO Component (1)

Gene RIF (9)

25447851 closest protein-coding genes were respectively GDF7 (rs3072), which encodes a ligand in the bone morphogenetic protein pathway, and TBX5 (rs2701108), which encodes a transcription factor that regulates esophageal and cardiac development
24155967 BMP12 induces tenogenic differentiation of adipose-derived stromal cells via the Smad1/5/8 pathway.
21702718 studies show that even though tenogenic (BMP 12 and BMP 13) and osteogenic (BMP2) BMPs bind the same receptors with high affinity they signal much differently and result in differential activation of osteogenic and tenogenic markers
20734064 Observational study of gene-disease association. (HuGE Navigator)
20677014 Observational study of gene-disease association. (HuGE Navigator)
20334610 induces ligamentogenic differentiation in mesenchymal progenitors
20237496 Observational study of gene-disease association. (HuGE Navigator)
20102312 stimulates expression of both chondrogenic and osteoblstic markers in pluripotent mesenchymal C3H10T1/2 cells.
12741987 In mouse, the expression of Gdf7 in roof plate cells is required for the fidelity of commissural axon growth.

AA Sequence

SPISILYIDAANNVVYKQYEDMVVEACGCR                                            421 - 450

Text Mined References (17)

PMID Year Title
26783083 2016 The Barrett-associated variants at GDF7 and TBX5 also increase esophageal adenocarcinoma risk.
26445383 2016 Effect of adipose-derived stromal cells and BMP12 on intrasynovial tendon repair: A biomechanical, biochemical, and proteomics study.
26033972 2015 Local rhBMP-12 on an Absorbable Collagen Sponge as an Adjuvant Therapy for Rotator Cuff Repair - A Phase 1, Randomized, Standard of Care Control, Multicenter Study: Safety and Feasibility.
25447851 2015 Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.
24155967 2013 BMP12 induces tenogenic differentiation of adipose-derived stromal cells.
21702718 2011 Divergent activities of osteogenic BMP2, and tenogenic BMP12 and BMP13 independent of receptor binding affinities.
20734064 2010 A large-scale candidate gene association study of age at menarche and age at natural menopause.
20677014 2010 An approach based on a genome-wide association study reveals candidate loci for narcolepsy.
20339536 2010 Genome-wide association of lipid-lowering response to statins in combined study populations.
20334610 2010 BMP12 and BMP13 gene transfer induce ligamentogenic differentiation in mesenchymal progenitor and anterior cruciate ligament cells.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
20102312 2010 Effects of cartilage-derived morphogenetic protein-3 on the expression of chondrogenic and osteoblastic markers in the pluripotent mesenchymal C3H10T1/2 cell line.
16049014 2005 Identification of receptors and signaling pathways for orphan bone morphogenetic protein/growth differentiation factor ligands based on genomic analyses.
15815621 2005 Generation and annotation of the DNA sequences of human chromosomes 2 and 4.
12741987 2003 A role for BMP heterodimers in roof plate-mediated repulsion of commissural axons.
10022976 1999 Isolation of zebrafish gdf7 and comparative genetic mapping of genes belonging to the growth/differentiation factor 5, 6, 7 subgroup of the TGF-beta superfamily.
9808626 1998 Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord.