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  6. Guanylate-binding protein 2

Tbio Guanylate-binding protein 2

Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions, but the major reaction product is GDP (PubMed:8706832). Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity).

This gene belongs to the guanine-binding protein (GBP) family, which includes interferon-induced proteins that can bind to guanine nucleotides (GMP, GDP and GTP). The encoded protein is a GTPase which hydrolyzes GTP, predominantly to GDP. The protein may play a role as a marker of squamous cell carcinomas. [provided by RefSeq, Jul 2013]

 Comments

Property Summary

NCBI Gene PubMed Count 21
PubMed Score 31.28
PubTator Score 19.15

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Liver Cirrhosis, Experimental 769 0.0 0.0
Myocardial Ischemia 169 0.0 0.0
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.8

Expression

  Differential Expression (35)

Disease log2 FC p
active Crohn's disease 1.986 1.2e-03
active ulcerative colitis 1.330 1.1e-02
acute quadriplegic myopathy 1.537 1.9e-07
adrenocortical carcinoma -1.978 1.5e-03
adult high grade glioma 2.300 3.8e-04
aldosterone-producing adenoma -1.692 2.6e-02
astrocytoma 1.300 1.6e-06
Astrocytoma, Pilocytic 3.200 2.2e-11
autosomal dominant Emery-Dreifuss muscul... 1.014 2.3e-03
Breast cancer -1.700 9.7e-08
chronic kidney disease 1.200 3.4e-02
Chronic Lymphocytic Leukemia 1.357 1.1e-04
colon cancer -1.300 5.2e-03
cystic fibrosis 1.517 4.9e-04
dermatomyositis 2.000 6.2e-03
diabetes mellitus -1.300 1.7e-03
Endometriosis -1.507 7.2e-03
ependymoma 1.500 3.3e-03
gastric carcinoma 1.200 2.3e-02
glioblastoma 1.900 6.6e-05
intraductal papillary-mucinous adenoma (... 1.400 2.6e-03
intraductal papillary-mucinous carcinoma... 1.900 4.9e-03
intraductal papillary-mucinous neoplasm ... 2.000 4.2e-03
juvenile dermatomyositis 2.162 1.2e-12
limb girdle muscular dystrophy 2I 1.202 2.9e-04
lung cancer -1.600 4.2e-04
lung carcinoma -2.600 4.3e-20
non primary Sjogren syndrome sicca -1.100 1.9e-02
ovarian cancer -1.200 2.5e-02
pancreatic cancer 1.200 5.4e-04
pancreatic ductal adenocarcinoma liver m... 1.173 2.0e-02
Pick disease 1.800 4.3e-02
pituitary cancer -1.500 1.7e-04
sarcoidosis 1.400 2.2e-02
subependymal giant cell astrocytoma 4.047 9.6e-04

Synonym

Accession P32456 Q6GPH0 Q6IAU2 Q86TB0
Symbols

Gene

GBP2

PANTHER Protein Class (3)

  Ortholog (2)

Species Source Disease
OMA EggNOG
Inparanoid OMA

 UniProt Keyword (12)

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 GO Function (2)

 GO Component (5)

 GO Process (3)

 Compartment GO Term (34)

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 IMPC Phenotype (4)

 MGI Phenotype (2)

 HCA RNA Cell Line (56)

See all...

Pathway (6)

Protein-protein Interaction (10)

GBP7   GBP3   HSP90AA1   HSP90AB1   HSP90AB3P   HSP90AA5P   ADD3   ADD1   PCBP3   HBA2  

Gene RIF (11)

AA Sequence 

MAPEINLPGPMSLIDNTKGQLVVNPEALKILSAITQPVVVVAIVGLYRTGKSYLMNKLAGKKNGFSLGST      1 - 70
VKSHTKGIWMWCVPHPKKPEHTLVLLDTEGLGDIEKGDNENDSWIFALAILLSSTFVYNSMGTINQQAMD     71 - 140
QLHYVTELTDRIKANSSPGNNSVDDSADFVSFFPAFVWTLRDFTLELEVDGEPITADDYLELSLKLRKGT    141 - 210
DKKSKSFNDPRLCIRKFFPKRKCFVFDWPAPKKYLAHLEQLKEEELNPDFIEQVAEFCSYILSHSNVKTL    211 - 280
SGGIPVNGPRLESLVLTYVNAISSGDLPCMENAVLALAQIENSAAVEKAIAHYEQQMGQKVQLPTETLQE    281 - 350
LLDLHRDSEREAIEVFMKNSFKDVDQMFQRKLGAQLEARRDDFCKQNSKASSDCCMALLQDIFGPLEEDV    351 - 420
KQGTFSKPGGYRLFTQKLQELKNKYYQVPRKGIQAKEVLKKYLESKEDVADALLQTDQSLSEKEKAIEVE    421 - 490
RIKAESAEAAKKMLEEIQKKNEEMMEQKEKSYQEHVKQLTEKMERDRAQLMAEQEKTLALKLQEQERLLK    491 - 560
EGFENESKRLQKDIWDIQMRSKSLEPICNIL                                           561 - 591
//

Text Mined References (25)

PMID Year Title