Tdark GAREM2 GRB2-associated and regulator of MAPK protein 2

Protein Summary

Description

Probable adapter protein that may provide a link between cell surface epidermal growth factor receptor and the MAPK/ERK signaling pathway.

Uniprot Accession IDs

• Q75VX8
• B5MC97
• B7WNK9
• Q8NF27
• Q9UIK8

Gene Name

• GAREM2

Ensembl ID

• ENST00000401533
• ENSP00000384593
• ENSG00000157833
• ENST00000407684
• ENSP00000384581

Symbol

• FAM59B
• GAREML
• KIAA2038
• FAM59B
• GAREML

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.96   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 66   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2.96   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 66   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0