Tbio GALNT3 Polypeptide N-acetylgalactosaminyltransferase 3

Protein Summary

Description

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis. This gene encodes UDP-GalNAc transferase 3, a member of the GalNAc-transferases family. This family transfers an N-acetyl galactosamine to the hydroxyl group of a serine or threonine residue in the first step of O-linked oligosaccharide biosynthesis. Individual GalNAc-transferases have distinct activities and initiation of O-glycosylation is regulated by a repertoire of GalNAc-transferases. The protein encoded by this gene is highly homologous to other family members, however the enzymes have different substrate specificities. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q14435
• Q53TG9
• Q7Z476

Gene Name

• GALNT3

Ensembl ID

• ENST00000392701
• ENSP00000376465
• ENSG00000115339

Symbol

• HHS
• HFTC
• HFTC1
• GalNAc-T3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	0.96
kinase perturbation	0.81
histone modification site profile	0.8
cellular component	0.72
gene perturbation	0.7

Protein Classes

PANTHER Classes

Protein / Transferase / Glycosyltransferase / Polypeptide N-acetylgalactosaminyltransferase 3

DTO Classes

Protein / Enzyme / Transferase / Glycosyltransferase / Polypeptide N-acetylgalactosaminyltransferase 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.12   (req: < 5)

Gene RIFs: 52   (req: <= 3)

Antibodies: 159   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.12   (req: >= 5)

Gene RIFs: 52   (req: > 3)

Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0