GALNT11
Polypeptide N-acetylgalactosaminyltransferase 11
Protein Summary
Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO).
- ENST00000415421
- ENSP00000410093
- ENSG00000178234
- ENST00000422997
- ENSP00000389449
- ENST00000430044
- ENSP00000395122
- ENST00000434507
- ENSP00000416787
- GALNACT11
- GALNAC-T11
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
virus perturbation | 0.99 | ||
histone modification site profile | 0.87 | ||
disease perturbation | 0.83 | ||
kinase perturbation | 0.81 | ||
transcription factor binding site profile | 0.76 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.93 (req: < 5)
Gene RIFs: 5 (req: <= 3)
Antibodies: 112 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 10.93 (req: >= 5)
Gene RIFs: 5 (req: > 3)
Antibodies: 112 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0