| Tbio | GA-binding protein subunit beta-1 |
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.
This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
This gene encodes the GA-binding protein transcription factor, beta subunit. This protein forms a tetrameric complex with the alpha subunit, and stimulates transcription of target genes. The encoded protein may be involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. The crystal structure of a similar protein in mouse has been resolved as a ternary protein complex. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung adenocarcinoma | 2716 | 8.0e-13 |
| malignant mesothelioma | 3232 | 1.0e-06 |
| osteosarcoma | 7950 | 1.3e-05 |
| atypical teratoid / rhabdoid tumor | 5112 | 6.4e-05 |
| group 3 medulloblastoma | 4104 | 1.3e-04 |
| primitive neuroectodermal tumor | 3035 | 1.7e-04 |
| glioblastoma | 5792 | 2.2e-04 |
| invasive ductal carcinoma | 2951 | 5.5e-04 |
| inflammatory breast cancer | 286 | 6.3e-04 |
| ovarian cancer | 8520 | 1.1e-03 |
| cutaneous lupus erythematosus | 1057 | 7.1e-03 |
| adult high grade glioma | 3801 | 9.3e-03 |
| tuberculosis | 2010 | 1.5e-02 |
| medulloblastoma, large-cell | 6241 | 2.9e-02 |
| Rheumatoid arthritis | 1191 | 3.4e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -1.800 | 9.3e-03 |
| atypical teratoid / rhabdoid tumor | -2.200 | 6.4e-05 |
| cutaneous lupus erythematosus | 1.100 | 7.1e-03 |
| glioblastoma | -1.200 | 2.2e-04 |
| group 3 medulloblastoma | 1.500 | 1.3e-04 |
| inflammatory breast cancer | -1.300 | 6.3e-04 |
| invasive ductal carcinoma | 1.300 | 5.5e-04 |
| lung adenocarcinoma | -1.500 | 8.0e-13 |
| malignant mesothelioma | 1.200 | 1.0e-06 |
| medulloblastoma, large-cell | -1.100 | 2.9e-02 |
| osteosarcoma | -1.442 | 1.3e-05 |
| ovarian cancer | 1.500 | 1.1e-03 |
| primitive neuroectodermal tumor | 1.200 | 1.7e-04 |
| Rheumatoid arthritis | 1.100 | 3.4e-02 |
| tuberculosis | -1.100 | 1.5e-02 |
MSLVDLGKKLLEAARAGQDDEVRILMANGAPFTTDWLGTSPLHLAAQYGHYSTTEVLLRAGVSRDARTKV 1 - 70 DRTPLHMAASEGHASIVEVLLKHGADVNAKDMLKMTALHWATEHNHQEVVELLIKYGADVHTQSKFCKTA 71 - 140 FDISIDNGNEDLAEILQIAMQNQINTNPESPDTVTIHAATPQFIIGPGGVVNLTGLVSSENSSKATDETG 141 - 210 VSAVQFGNSSTSVLATLAALAEASAPLSNSSETPVVATEEVVTAESVDGAIQQVVSSGGQQVITIVTDGI 211 - 280 QLGNLHSIPTSGIGQPIIVTMPDGQQVLTVPATDIAEETVISEEPPAKRQCIEIIENRVESAEIEEREAL 281 - 350 QKQLDEANREAQKYRQQLLKKEQEAEAYRQKLEAMTRLQTNKEAV 351 - 395 //
