| Tbio | GA-binding protein alpha chain |
Transcription factor capable of interacting with purine rich repeats (GA repeats). Necessary for the expression of the Adenovirus E4 gene.
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]
This gene encodes one of three GA-binding protein transcription factor subunits which functions as a DNA-binding subunit. Since this subunit shares identity with a subunit encoding the nuclear respiratory factor 2 gene, it is likely involved in activation of cytochrome oxidase expression and nuclear control of mitochondrial function. This subunit also shares identity with a subunit constituting the transcription factor E4TF1, responsible for expression of the adenovirus E4 gene. Because of its chromosomal localization and ability to form heterodimers with other polypeptides, this gene may play a role in the Down Syndrome phenotype. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Oct 2010]
Comments
| Disease | Target Count |
|---|---|
| Depressive disorder | 409 |
| Fetal Alcohol Spectrum Disorders | 13 |
| Fetal alcohol syndrome | 22 |
| Disease | Target Count | P-value |
|---|---|---|
| ependymoma | 4679 | 1.7e-06 |
| glioblastoma | 5792 | 4.0e-06 |
| atypical teratoid/rhabdoid tumor | 357 | 2.2e-04 |
| Astrocytoma, Pilocytic | 3081 | 3.4e-04 |
| group 4 medulloblastoma | 1855 | 5.0e-04 |
| ovarian cancer | 8520 | 1.1e-03 |
| adult high grade glioma | 3801 | 1.4e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Down syndrome | 499 | 3.281 | 1.6 |
| Aseptic Meningitis | 6 | 3.14 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.100 | 1.4e-02 |
| Astrocytoma, Pilocytic | 1.200 | 3.4e-04 |
| atypical teratoid/rhabdoid tumor | 1.100 | 2.2e-04 |
| ependymoma | 1.300 | 1.7e-06 |
| glioblastoma | 1.300 | 4.0e-06 |
| group 4 medulloblastoma | 1.600 | 5.0e-04 |
| ovarian cancer | -1.200 | 1.1e-03 |
MTKREAEELIEIEIDGTEKAECTEESIVEQTYAPAECVSQAIDINEPIGNLKKLLEPRLQCSLDAHEICL 1 - 70 QDIQLDPERSLFDQGVKTDGTVQLSVQVISYQGIEPKLNILEIVKPADTVEVVIDPDAHHAESEAHLVEE 71 - 140 AQVITLDGTKHITTISDETSEQVTRWAAALEGYRKEQERLGIPYDPIQWSTDQVLHWVVWVMKEFSMTDI 141 - 210 DLTTLNISGRELCSLNQEDFFQRVPRGEILWSHLELLRKYVLASQEQQMNEIVTIDQPVQIIPASVQSAT 211 - 280 PTTIKVINSSAKAAKVQRAPRISGEDRSSPGNRTGNNGQIQLWQFLLELLTDKDARDCISWVGDEGEFKL 281 - 350 NQPELVAQKWGQRKNKPTMNYEKLSRALRYYYDGDMICKVQGKRFVYKFVCDLKTLIGYSAAELNRLVTE 351 - 420 CEQKKLAKMQLHGIAQPVTAVALATASLQTEKDN 421 - 454 //
