You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
G2E3
G2/M phase-specific E3 ubiquitin-protein ligase

Protein Summary
Description
E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Essential in early embryonic development to prevent apoptotic death.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000206595
  • ENSP00000206595
  • ENSG00000092140

Symbol
  • KIAA1333
  • PHF7B
  • KIAA1333
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.88
protein domain
0.85
transcription factor binding site profile
0.83
microRNA
0.81
PubMedID
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.63   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 113   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 7.63   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 113   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0