You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
FZR1
Fizzy-related protein homolog

Protein Summary
Description
Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313639
  • ENSP00000321800
  • ENSG00000105325
  • ENST00000395095
  • ENSP00000378529
  • ENST00000441788
  • ENSP00000410369

Symbol
  • CDH1
  • FYR
  • FZR
  • KIAA1242
  • FZR
  • CDH1
  • FZR2
  • HCDH
  • HCDH1
  • CDC20C
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.93
biological process
0.91
small molecule perturbation
0.77
transcription factor
0.76
interacting protein
0.7


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.52   (req: < 5)
Gene RIFs: 79   (req: <= 3)
Antibodies: 317   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.52   (req: >= 5)
Gene RIFs: 79   (req: > 3)
Antibodies: 317   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0