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Tclin
FYN
Tyrosine-protein kinase Fyn

Protein Summary
Description
Non-receptor tyrosine-protein kinase that plays a role in many biological processes including regulation of cell growth and survival, cell adhesion, integrin-mediated signaling, cytoskeletal remodeling, cell motility, immune response and axon guidance. Inactive FYN is phosphorylated on its C-terminal tail within the catalytic domain. Following activation by PKA, the protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1 phosphorylation, activation and targeting to focal adhesions. Involved in the regulation of cell adhesion and motility through phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-catenin). Regulates cytoskeletal remodeling by phosphorylating several proteins including the actin regulator WAS and the microtubule-associated proteins MAP2 and MAPT. Promotes cell survival by phosphorylating AGAP2/PIKE-A and preventing its apoptotic cleavage. Participates in signal transduction pathways that regulate the integrity of the glomerular slit diaphragm (an essen ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000229471
  • ENSP00000229471
  • ENSG00000010810
  • ENST00000354650
  • ENSP00000346671
  • ENST00000368667
  • ENSP00000357656
  • ENST00000368678
  • ENSP00000357667
  • ENST00000368682
  • ENSP00000357671
  • ENST00000538466
  • ENSP00000440646

Symbol
  • SLK
  • SYN
  • p59-FYN
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
hub protein
1
molecular function
1
virus
1
viral protein
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1383.47   (req: < 5)
Gene RIFs: 183   (req: <= 3)
Antibodies: 933   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1383.47   (req: >= 5)
Gene RIFs: 183   (req: > 3)
Antibodies: 933   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 84
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 75
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 5