| Tbio | FXYD domain-containing ion transport regulator 3 |
Induces a hyperpolarization-activated chloride current when expressed in Xenopus oocytes. May be a modulator capable of activating endogenous oocyte channels.
This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Comments
| Disease | Target Count |
|---|---|
| Pancreatic Neoplasm | 79 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8491 | 2.4e-10 |
| intraductal papillary-mucinous adenoma (IPMA) | 2956 | 5.2e-06 |
| osteosarcoma | 7933 | 7.4e-06 |
| ulcerative colitis | 2087 | 7.5e-06 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3289 | 1.9e-05 |
| pancreatic cancer | 2300 | 2.5e-05 |
| medulloblastoma, large-cell | 6234 | 6.2e-05 |
| interstitial cystitis | 2299 | 2.2e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2988 | 3.1e-04 |
| colon cancer | 1475 | 5.4e-04 |
| ductal carcinoma in situ | 1745 | 1.9e-03 |
| adult high grade glioma | 2148 | 1.9e-03 |
| lung cancer | 4473 | 3.1e-03 |
| atypical teratoid / rhabdoid tumor | 4369 | 6.0e-03 |
| invasive ductal carcinoma | 2950 | 1.2e-02 |
| Disease | log2 FC | p |
|---|---|---|
| osteosarcoma | 1.995 | 7.4e-06 |
| atypical teratoid / rhabdoid tumor | 1.200 | 6.0e-03 |
| medulloblastoma, large-cell | 1.600 | 6.2e-05 |
| intraductal papillary-mucinous adenoma (... | 1.900 | 5.2e-06 |
| intraductal papillary-mucinous carcinoma... | 2.400 | 3.1e-04 |
| intraductal papillary-mucinous neoplasm ... | 3.000 | 1.9e-05 |
| colon cancer | -3.000 | 5.4e-04 |
| lung cancer | -2.100 | 3.1e-03 |
| pancreatic cancer | 1.500 | 2.5e-05 |
| interstitial cystitis | -2.500 | 2.2e-04 |
| adult high grade glioma | 1.300 | 1.9e-03 |
| ductal carcinoma in situ | 1.500 | 1.9e-03 |
| invasive ductal carcinoma | 1.600 | 1.2e-02 |
| ulcerative colitis | -2.000 | 7.5e-06 |
| ovarian cancer | 1.900 | 2.4e-10 |
| PMID | Text | |
|---|---|---|
| 26740212 | Suppression of FXYD3 in MCF-7. | |
| 26410457 | Study demonstrated that the expression of FXYD1, FXYD3 and FXYD5 is elevated in the lungs of Acute respiratory distress syndrome patients | |
| 22430872 | All three markers correlated significantly with regional lymph node metastasis: FXYD3 (p = 0.0110), S100A11 (p = 0.0071), and GSTM3 (p = 0.0173) in colon cancer lymphatic metastasis. | |
| 20805335 | ExoS facilitates P. aeruginosa penetration through the intestinal epithelial barrier by binding to FXYD3 and thereby impairing the defense function of tight junctions against bacterial penetration. | |
| 20364041 | Up-regulated expression of FXYD-3 protein may be involved in tumourgenesis and invasion of gastric adenocarcinoma. | |
| 20112499 | Upregulation of FXYD3 is associated with glioma. | |
| 19955746 | FXYD3 expression is related to several biological variables including ras, p53, legumain and PCNA, and may be involved in the development of the relatively early stages of colorectal cancers | |
| 19893046 | inactivation of FXYD3 through a gene mutation or unknown mechanism could be one cause of the atypical shapes of cancer cells and play a potential role in the progression of lung cancer. | |
| 19571376 | FXYD3a protein is highly expressed in breast cancers, and responsible for cancer cell proliferation. | |
| 19109419 | FXYD3 silencing prevents proper regulation of Na,K-ATPase, which leads to perturbation of cellular Na+ and K+ homeostasis and changes in the expression of Na,K-ATPase isozymes, whose functional properties are incompatible with cell differentiation. | |
| 18000745 | structures of the FXYD proteins (with emphasis on 1-4), as well as their dynamics and their associations with the lipid | |
| 17409496 | FXYD3 interacts with Na(+)-K(+)-Exchanging ATPase in colorectal neoplasms. | |
| 17077088 | analysis of two human FXYD3 isoforms that are differentially expressed in differentiated and non-differentiated cells with different functional properties | |
| 16288923 | show that the helical regions and connecting segments of FXYD1, FXYD3, and FXYD4 determined in micelles by NMR spectroscopy coincide with the positions of intron-exon junctions in the genes | |
| 16003754 | overexpression of FXYD3 in pancreatic cancer may contribute to the proliferative activity of this malignancy | |
| 14654946 | Results indicate that the human MAT-8 gene contains the potential to serve as a prostate cancer expression marker and that MAT-8 plays an important role in cellular growth of prostate carcinomas. | |
| 12535606 | molecular cloning, protein expression, sequencing and NMR structure determination |
| PMID | Year | Title | |
|---|---|---|---|
| 26740212 | 2016 | Silencing overexpression of FXYD3 protein in breast cancer cells amplifies effects of doxorubicin and ?-radiation on Na(+)/K(+)-ATPase and cell survival. | |
| 26410457 | 2016 | FXYD1 negatively regulates Na(+)/K(+)-ATPase activity in lung alveolar epithelial cells. | |
| 22430872 | 2012 | Tissue-based proteomics reveals FXYD3, S100A11 and GSTM3 as novel markers for regional lymph node metastasis in colon cancer. | |
| 20805335 | 2010 | Translocation of Pseudomonas aeruginosa from the intestinal tract is mediated by the binding of ExoS to an Na,K-ATPase regulator, FXYD3. | |
| 20364041 | 2010 | Expression and significance of FXYD-3 protein in gastric adenocarcinoma. | |
| 20112499 | 2009 | FXYD3 expression in gliomas and its clinicopathological significance. | |
| 19955746 | 2009 | Expression of FXYD3 protein in relation to biological and clinicopathological variables in colorectal cancers. | |
| 19893046 | 2009 | Down-regulation of FXYD3 expression in human lung cancers: its mechanism and potential role in carcinogenesis. | |
| 19571376 | 2009 | FXYD3 protein involved in tumor cell proliferation is overproduced in human breast cancer tissues. | |
| 19199708 | 2009 | Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). | |
| 19109419 | 2009 | A link between FXYD3 (Mat-8)-mediated Na,K-ATPase regulation and differentiation of Caco-2 intestinal epithelial cells. | |
| 18000745 | 2007 | Structures of the FXYD regulatory proteins in lipid micelles and membranes. | |
| 17409496 | 2007 | Interaction of Mat-8 (FXYD-3) with Na+/K+-ATPase in colorectal cancer cells. | |
| 17077088 | 2006 | Structural and functional properties of two human FXYD3 (Mat-8) isoforms. | |
| 16712791 | 2006 | Identification of intrahepatic cholangiocarcinoma related genes by comparison with normal liver tissues using expressed sequence tags. | |
| 16344560 | 2006 | Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. | |
| 16288923 | 2005 | Correlation of gene and protein structures in the FXYD family proteins. | |
| 16003754 | 2006 | FXYD3 is overexpressed in pancreatic ductal adenocarcinoma and influences pancreatic cancer cell growth. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15057824 | 2004 | The DNA sequence and biology of human chromosome 19. | |
| 14654946 | 2004 | Up-regulated expression of the MAT-8 gene in prostate cancer and its siRNA-mediated inhibition of expression induces a decrease in proliferation of human prostate carcinoma cells. | |
| 12535606 | 2003 | Expression and characterization of the FXYD ion transport regulators for NMR structural studies in lipid micelles and lipid bilayers. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 10950925 | 2000 | The FXYD gene family of small ion transport regulators or channels: cDNA sequence, protein signature sequence, and expression. | |
| 8521420 | 1995 | Identification of melanoma inhibitory activity and other differentially expressed messenger RNAs in human melanoma cell lines with different metastatic capacity by messenger RNA differential display. | |
| 7836447 | 1995 | Mat-8, a novel phospholemman-like protein expressed in human breast tumors, induces a chloride conductance in Xenopus oocytes. | |
| 7566098 | 1995 | Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence. |
