| Tbio | FXYD domain-containing ion transport regulator 3 |
Isoform 2: Decreases the apparent K+ affinity of the sodium/potassium-transporting ATPase only at slightly negative and positive membrane potentials and increases the apparent Na+ affinity over a large range of membrane potentials.
This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
This gene belongs to a small family of FXYD-domain containing regulators of Na+/K+ ATPases which share a 35-amino acid signature sequence domain, beginning with the sequence PFXYD, and containing 7 invariant and 6 highly conserved amino acids. This gene encodes a cell membrane protein that may regulate the function of ion-pumps and ion-channels. This gene may also play a role in tumor progression. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Pancreatic Neoplasms | 85 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Pancreatic Neoplasm | 85 |
| Disease | Target Count | P-value |
|---|---|---|
| ovarian cancer | 8520 | 2.4e-10 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 5.2e-06 |
| osteosarcoma | 7950 | 7.4e-06 |
| ulcerative colitis | 1819 | 7.5e-06 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 1.9e-05 |
| pancreatic cancer | 2398 | 2.5e-05 |
| medulloblastoma, large-cell | 6241 | 6.2e-05 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 3.1e-04 |
| colon cancer | 1478 | 5.4e-04 |
| ductal carcinoma in situ | 1745 | 1.9e-03 |
| adult high grade glioma | 3801 | 1.9e-03 |
| lung cancer | 4740 | 3.1e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 6.0e-03 |
| invasive ductal carcinoma | 2951 | 1.2e-02 |
| interstitial cystitis | 2312 | 2.4e-02 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.300 | 1.9e-03 |
| atypical teratoid / rhabdoid tumor | 1.200 | 6.0e-03 |
| colon cancer | -3.000 | 5.4e-04 |
| ductal carcinoma in situ | 1.500 | 1.9e-03 |
| interstitial cystitis | -1.500 | 2.4e-02 |
| intraductal papillary-mucinous adenoma (... | 1.900 | 5.2e-06 |
| intraductal papillary-mucinous carcinoma... | 2.400 | 3.1e-04 |
| intraductal papillary-mucinous neoplasm ... | 3.000 | 1.9e-05 |
| invasive ductal carcinoma | 1.600 | 1.2e-02 |
| lung cancer | -2.100 | 3.1e-03 |
| medulloblastoma, large-cell | 1.600 | 6.2e-05 |
| osteosarcoma | 1.995 | 7.4e-06 |
| ovarian cancer | 1.900 | 2.4e-10 |
| pancreatic cancer | 1.500 | 2.5e-05 |
| ulcerative colitis | -2.000 | 7.5e-06 |
