Property Summary

NCBI Gene PubMed Count 34
PubMed Score 11.30
PubTator Score 38.75

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Synonym

Accession Q8N4E7
Symbols MTF

Gene

PANTHER Protein Class (1)

PDB

1R03  

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (27)

PMID Text
23573868 experimental overexpression of FTMT may modify mitochondrial iron availability and lead to ineffective erythropoiesis
22706241 FtMt mutation may determine a condition similar to haploinsufficiency resulting in a reduced protection from iron-dependent oxidative stress in mitochondria
21799823 MtF is involved in the pathology of Alzheimer's disease and may play a neuroprotective role against oxidative stress
21712541 Stat5-dependent transcriptional regulation is displaced by strong cytosolic iron starvation status induced by mitochondrial ferritin.
21616139 higher protein levels in prostate cancer cells expressing a dominant negative mutant of p66Shc
20939738 The analysis suggests that sequence variations in the coding region of FtMt are not involved in the development of myelodysplastic syndromes and Parkinson's disease.
20939738 Observational study of gene-disease association. (HuGE Navigator)
20877624 Observational study of gene-disease association. (HuGE Navigator)
20526373 Primary spontaneous pneumothorax in smokers is associated with lung macrophage oxidative stress. The response to this condition involves HIF-1alpha-mediated induction of HO-1, BVR and H-ferritin.
20369475 MtF expression is downregulated during ATRA-induced K562 cell differentiation, with concomitant downregulation of TfR1 and upregulation of Fn.
19816198 Increased numbers of mitochondria in neurons in restless legs syndrome (RLS) and increased mitochondrial ferritin might contribute to insufficient cytosolic iron levels in RLS substantia nigra neurons.
19585161 Data present density functional theory optimizations of structures of dizinc(II) complexes with a model of the ferroxidase center of human H ferritin, and the results compared with the crystallographically determined structure of the complex.
18815198 FtMt expression in fibroblasts from Friedreich ataxia patients prevented the formation of reactive oxygen species and partially rescued the impaired activity of mitochondrial Fe-S enzymes.
18805796 ferritin pore gating influences to the amount of iron (59Fe) in ferritin in vivo
18372207 p53 overexpression strongly downregulates the transcriptional efficiency driven by an H ferritin promoter construct containing only the NF-Y recognition sequence.
18325346 ferritin H transcription is activated by rotenone via an oxidative stress-mediated pathway leading to antioxidant-responsive element activation
18160053 Frataxin has some roles in controlling the balance between different mitochondrial iron pools that are partially in common with those of mitochondrial ferritin.
18076382 ionomycin-mediated induction of ferritin H may occur in an NFAT-independent manner but through post-transcriptional stabilization of the ferritin H mRNA.
17565989 PIAS3 is a new regulator of ATF1 that regulates the ARE-mediated transcription of the ferritin H gene
17459943 Demonstrated iron uptake by ferritins into multiple organs. Uptake is greater when iron delivered by H-ferritin compared to L-ferritin.
16797877 functional analysis of an H ferritin promoter allele carrying a G to T substitution adjacent to the Bbf binding site, in position -69
16537925 These results suggest that hemin activates the transcription of the ferritin H gene during K562 erythroid differentiation by Ref-1-mediated activation of these b-zip transcription factors to the Antioxidant-responsive Elements.
16448386 ferritin H not only responds to changes in tissue iron (its classic role), but can actively regulate overall tissue iron balance
15755449 Data reveal striking differences in iron oxidation and hydrolysis chemistry between human mitochondrial ferritin and human H-chain ferritin despite their similar diiron ferroxidase centers.
15065877 In contrast to previously published literature, this study demonstrates that the putative nucleation site does not play an important role in iron uptake or mineralization in H-chain ferritin.
12406866 RT-PCR studies showed MtF mRNA in circulating reticulocytes of 2 X-linked sideroblastic anemia patients but not controls. Most of the iron in perinuclear mitochondria of ring sideroblasts is in the form of MtF, a specific marker of sideroblastic anemia.
11953424 Human mitochondrial ferritin expressed in HeLa cells incorporates iron and affects cellular iron metabolism

AA Sequence

MLSCFRLLSRHISPSLASLRPVRCCFALPLRWAPGRPLDPRQIAPRRPLAAAASSRDPTGPAAGPSRVRQ      1 - 70
NFHPDSEAAINRQINLELYASYVYLSMAYYFSRDDVALNNFSRYFLHQSREETEHAEKLMRLQNQRGGRI     71 - 140
RLQDIKKPEQDDWESGLHAMECALLLEKNVNQSLLELHALASDKGDPHLCDFLETYYLNEQVKSIKELGD    141 - 210
HVHNLVKMGAPDAGLAEYLFDTHTLGNENKQN                                          211 - 242
//

Text Mined References (34)

PMID Year Title
25140149 2014 Genetic variation modifies risk for neurodegeneration based on biomarker status.
25133637 2014 Genome-wide association studies and heritability estimates of body mass index related phenotypes in Bangladeshi adults.
23897914 2013 A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
23573868 2013 Effects of mitochondrial ferritin overexpression in normal and sideroblastic erythroid progenitors.
22706241 2012 Study of FTMT and ABCA4 genes in a patient affected by age-related macular degeneration: identification and analysis of new mutations.
21799823 2011 Expression and localization of mitochondrial ferritin mRNA in Alzheimer's disease cerebral cortex.
21712541 2011 Over-expression of mitochondrial ferritin affects the JAK2/STAT5 pathway in K562 cells and causes mitochondrial iron accumulation.
21630459 2011 Proteomic characterization of the human sperm nucleus.
21616139 2011 P66Shc mediated ferritin degradation--a novel mechanism of ROS formation.
20939738 2010 Sequence variations in mitochondrial ferritin: distribution in healthy controls and different types of patients.
20877624 2010 Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
20526373 2010 Induction of heme oxygenase-1, biliverdin reductase and H-ferritin in lung macrophage in smokers with primary spontaneous pneumothorax: role of HIF-1alpha.
20369475 2010 [Expression of mitochondrial ferritin in K562 leukemic cell during ATRA-induced cell differentiation].
19816198 2009 Mitochondrial ferritin in the substantia nigra in restless legs syndrome.
19585161 2009 Computational modeling of the dizinc-ferroxidase complex of human H ferritin: direct comparison of the density functional theory calculated and experimental structures.
18815198 2009 Mitochondrial ferritin limits oxidative damage regulating mitochondrial iron availability: hypothesis for a protective role in Friedreich ataxia.
18805796 2008 Ferritin contains less iron (59Fe) in cells when the protein pores are unfolded by mutation.
18372207 2008 p53-mediated downregulation of H ferritin promoter transcriptional efficiency via NF-Y.
18325346 2008 Role and regulation of ferritin H in rotenone-mediated mitochondrial oxidative stress.
18160053 2008 The effects of frataxin silencing in HeLa cells are rescued by the expression of human mitochondrial ferritin.
18076382 2008 Elevated intracellular calcium increases ferritin H expression through an NFAT-independent post-transcriptional mechanism involving mRNA stabilization.
17565989 2007 PIAS3 interacts with ATF1 and regulates the human ferritin H gene through an antioxidant-responsive element.
17459943 2007 Ferritin: a novel mechanism for delivery of iron to the brain and other organs.
16797877 2006 Detection and functional analysis of an SNP in the promoter of the human ferritin H gene that modulates the gene expression.
16537925 2006 Hemin-mediated regulation of an antioxidant-responsive element of the human ferritin H gene and role of Ref-1 during erythroid differentiation of K562 cells.
16448386 2006 Tissue-specific expression of ferritin H regulates cellular iron homoeostasis in vivo.
15755449 2005 Unique iron binding and oxidation properties of human mitochondrial ferritin: a comparative analysis with Human H-chain ferritin.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15201052 2004 Crystal structure and biochemical properties of the human mitochondrial ferritin and its mutant Ser144Ala.
15065877 2004 The putative "nucleation site" in human H-chain ferritin is not required for mineralization of the iron core.
12547228 Mitochondrial ferritin: a new player in iron metabolism.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12406866 2003 Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia.
11323407 2001 A human mitochondrial ferritin encoded by an intronless gene.