Property Summary

NCBI Gene PubMed Count 22
PubMed Score 0.00
PubTator Score 17.33

Knowledge Summary


No data available



  Differential Expression (2)

Disease log2 FC p
medulloblastoma, large-cell -1.300 3.8e-05
adult high grade glioma -1.100 6.7e-04

Gene RIF (15)

26363219 Tax-mediated transcriptional induction of Fascin requires NF-kappaB- and TRR-dependent promoter activation, and a promoter-independent, but PP2-sensitive signaling pathway.
24414419 Data indicate the specific contribution of fascin and cortactin during invadopodium formation.
24070574 the serum fascin level is an effective indicator of tumor aggressiveness, and that it plays an important role in the prognosis of NSCLC, particularly for non-distant metastatic patients.
21975552 The filopodium: a stable structure with highly regulated repetitive cycles of elongation and persistence depending on the actin cross-linker fascin
20410808 Fascin expression predicts survival after potentially curative resection of node-positive colon cancer.
19473443 expression may play an essential role in regulation of progression of oral squamous cell carcinoma and contributes to the event of epithelial-mesenchymal transition in the early aggressiveness of OSCC
19207554 Higher fascin scores correlated positively with tumor differentiation of esophageal SqCC. Significantly worse prognosis in patients with high scores of fascin, poor differentiation, T4 stage, positive for lymph node metastasis and distant metastasis
18498068 In ovarian tumors fascin is associated with certain features of increased tumor aggressiveness.
18450588 Real-time PCR-based genotyping method developed here is useful for investigations of allelic asymmetries within genomic regions with variations found in retinitis pigmentosa and retinl degeneration.
18450588 Observational study of gene-disease association. (HuGE Navigator)
17251446 The 208delG mutation in FSCN2 is not associated with hereditary retinal degeneration in the Chinese individuals examined.
16280978 Observational study of gene-disease association. (HuGE Navigator)
16280978 The photoreceptor-specific FSCN2 gene showed a relatively high number of sequence variations.
14661542 Observational study of genotype prevalence. (HuGE Navigator)
14609921 The 208delG mutation in the FSCN2 gene produces not only autosomal dominant retinitis pigmentosa but also ADMD (autosomal dominant macular degeneration)

AA Sequence

EY                                                                        491 - 492

Text Mined References (22)

PMID Year Title
26363219 2015 Regulation of the tumor marker Fascin by the viral oncoprotein Tax of human T-cell leukemia virus type 1 (HTLV-1) depends on promoter activation and on a promoter-independent mechanism.
24414419 2014 Stratifying fascin and cortactin function in invadopodium formation using inhibitory nanobodies and targeted subcellular delocalization.
24070574 2013 Serological investigation of the clinical significance of fascin in non-small-cell lung cancer.
21975552 The filopodium: a stable structure with highly regulated repetitive cycles of elongation and persistence depending on the actin cross-linker fascin.
20410808 2010 Fascin expression predicts survival after potentially curative resection of node-positive colon cancer.
19473443 2009 Effects of small interfering RNAs targeting Fascin on gene expression in oral cancer cells.
19207554 2009 Cortactin, fascin, and survivin expression associated with clinicopathological parameters in esophageal squamous cell carcinoma.
18498068 2008 Fascin in ovarian epithelial tumors.
18450588 2008 Allelic copy number variation in FSCN2 detected using allele-specific genotyping and multiplex real-time PCRs.
17286855 2007 Mapping of transcription start sites of human retina expressed genes.
17251446 2007 The 208delG mutation in FSCN2 does not associate with retinal degeneration in Chinese individuals.
16625196 2006 DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.
16280978 2005 Sequence variations in the retinal fascin FSCN2 gene in a Spanish population with autosomal dominant retinitis pigmentosa or macular degeneration.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14661542 2003 [Molecular genetic analysis for Japanese patients with autosomal dominant retinitis pigmentosa].
14609921 2003 Autosomal dominant macular degeneration associated with 208delG mutation in the FSCN2 gene.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11527955 2001 Mutation of human retinal fascin gene (FSCN2) causes autosomal dominant retinitis pigmentosa.
10892848 2000 Retinal fascin: functional nature, subcellular distribution, and chromosomal localization.
10783262 2000 Characterization of human retinal fascin gene (FSCN2) at 17q25: close physical linkage of fascin and cytoplasmic actin genes.
10234509 1999 Refinement of the RP17 locus for autosomal dominant retinitis pigmentosa, construction of a YAC contig and investigation of the candidate gene retinal fascin.
8889549 1996 Generation and analysis of 280,000 human expressed sequence tags.