Tdark FRYL Protein furry homolog-like

Protein Summary

Description

Plays a key role in maintaining the integrity of polarized cell extensions during morphogenesis, regulates the actin cytoskeleton and plays a key role in patterning sensory neuron dendritic fields by promoting avoidance between homologous dendrites as well as by limiting dendritic branching (By similarity). May function as a transcriptional activator.

Uniprot Accession IDs

• O94915
• O95640
• Q8WTZ5
• Q9NT40

Gene Name

• FRYL

Ensembl ID

• ENST00000358350
• ENSP00000351113
• ENSG00000075539
• ENST00000503238
• ENSP00000426064

Symbol

• AF4P12
• KIAA0826
• MOR2
• AF4p12
• KIAA0826

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
co-expressed gene	1
disease perturbation	0.95
transcription factor binding site profile	0.82
transcription factor perturbation	0.8
protein domain	0.73

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 27   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.05   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 27   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0