Tbio FRS2 Fibroblast growth factor receptor substrate 2

Protein Summary

Description

Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.

Uniprot Accession IDs

• Q8WU20
• B0LPF2
• B2R684
• O43558
• Q7LDQ6
• FGFR substrate 2

Gene Name

• FRS2

Ensembl ID

• ENST00000397997
• ENSP00000381083
• ENSG00000166225
• ENST00000549921
• ENSP00000450048
• ENST00000550389
• ENSP00000447241

Symbol

• SNT
• SNT1
• FRS1A
• FRS2A
• SNT-1
• FRS2alpha

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.98
virus perturbation	0.95
transcription factor binding site profile	0.92
biological process	0.91
microRNA	0.8

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.18   (req: < 5)

Gene RIFs: 41   (req: <= 3)

Antibodies: 469   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 172.18   (req: >= 5)

Gene RIFs: 41   (req: > 3)

Antibodies: 469   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 29

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0