| Tbio | FERM and PDZ domain-containing protein 4 |
Positive regulator of dendritic spine morphogenesis and density. Required for the maintenance of excitatory synaptic transmission. Binds phosphatidylinositol 4,5-bisphosphate.
This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. [provided by RefSeq, Jan 2010]
This gene encodes a multi-domain (WW, PDZ, FERM) containing protein. Through its interaction with other proteins (such as PSD-95), it functions as a positive regulator of dendritic spine morphogenesis and density, and is required for the maintenance of excitatory synaptic transmission. [provided by RefSeq, Jan 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Autistic Disorder | 364 | 0.0 | 0.0 |
| MENTAL RETARDATION, X-LINKED 104 | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2843 | 7.6e-16 |
| glioblastoma | 5792 | 5.8e-14 |
| Astrocytoma, Pilocytic | 3081 | 3.6e-13 |
| psoriasis | 6694 | 7.1e-09 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.8e-08 |
| malignant mesothelioma | 3232 | 8.3e-08 |
| adult high grade glioma | 3801 | 9.9e-07 |
| primitive neuroectodermal tumor | 3035 | 6.8e-06 |
| medulloblastoma, large-cell | 6241 | 4.9e-05 |
| ependymoma | 4679 | 5.5e-04 |
| group 3 medulloblastoma | 4104 | 9.9e-04 |
| astrocytic glioma | 2597 | 1.1e-03 |
| oligodendroglioma | 2850 | 4.4e-03 |
| osteosarcoma | 7950 | 4.8e-03 |
| Disease | Target Count |
|---|---|
| non-syndromic X-linked intellectual disability | 20 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | -2.700 | 9.9e-07 |
| astrocytic glioma | -2.300 | 1.1e-03 |
| Astrocytoma, Pilocytic | -3.000 | 3.6e-13 |
| atypical teratoid / rhabdoid tumor | -2.800 | 1.8e-08 |
| ependymoma | -2.600 | 5.5e-04 |
| glioblastoma | -2.800 | 5.8e-14 |
| group 3 medulloblastoma | -1.700 | 9.9e-04 |
| lung carcinoma | 2.000 | 7.6e-16 |
| malignant mesothelioma | -4.000 | 8.3e-08 |
| medulloblastoma, large-cell | -3.000 | 4.9e-05 |
| oligodendroglioma | -2.000 | 4.4e-03 |
| osteosarcoma | 1.075 | 4.8e-03 |
| primitive neuroectodermal tumor | -3.000 | 6.8e-06 |
| psoriasis | -1.200 | 7.1e-09 |
| Species | Source | Disease |
|---|---|---|
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| OMA EggNOG |
MDVFSFVKIAKLSSHRTKSSGWPPPSGTWGLSQVPPYGWEMTANRDGRDYFINHMTQAIPFDDPRLESCQ 1 - 70 IIPPAPRKVEMRRDPVLGFGFVAGSEKPVVVRSVTPGGPSEGKLIPGDQIVMINDEPVSAAPRERVIDLV 71 - 140 RSCKESILLTVIQPYPSPKSAFISAAKKARLKSNPVKVRFSEEVIINGQVSETVKDNSLLFMPNVLKVYL 141 - 210 ENGQTKSFRFDCSTSIKDVILTLQEKLSIKGIEHFSLMLEQRTEGAGTKLLLLHEQETLTQVTQRPSSHK 211 - 280 MRCLFRISFVPKDPIDLLRRDPVAFEYLYVQSCNDVVQERFGPELKYDIALRLAALQMYIATVTTKQTQK 281 - 350 ISLKYIEKEWGLETFLPSAVLQSMKEKNIKKALSHLVKANQNLVPPGKKLSALQAKVHYLKFLSDLRLYG 351 - 420 GRVFKATLVQAEKRSEVTLLVGPRYGISHVINTKTNLVALLADFSHVNRIEMFSEEESLVRVELHVLDVK 421 - 490 PITLLMESSDAMNLACLTAGYYRLLVDSRRSIFNMANKKNTATQETGPENKGKHNLLGPDWNCIPQMTTF 491 - 560 IGEGEQEAQITYIDSKQKTVEITDSTMCPKEHRHLYIDNAYSSDGLNQQLSQPGEAPCEADYRSLAQRSL 561 - 630 LTLSGPETLKKAQESPRGAKVSFIFGDFALDDGISPPTLGYETLLDEGPEMLEKQRNLYIGSANDMKGLD 631 - 700 LTPEAEGIQFVENSVYANIGDVKSFQAAEGIEEPLLHDICYAENTDDAEDEDEVSCEEDLVVGEMNQPAI 701 - 770 LNLSGSSDDIIDLTSLPPPEGDDNEDDFLLRSLNMAIAAPPPGFRDSSDEEDSQSQAASFPEDKEKGSSL 771 - 840 QNDEIPVSLIDAVPTSAEGKCEKGLDNAVVSTLGALEALSVSEEQQTSDNSGVAILRAYSPESSSDSGNE 841 - 910 TNSSEMTESSELATAQKQSENLSRMFLATHEGYHPLAEEQTEFPASKTPAGGLPPKSSHALAARPATDLP 911 - 980 PKVVPSKQLLHSDHMEMEPETMETKSVTDYFSKLHMGSVAYSCTSKRKSKLADGEGKAPPNGNTTGKKQQ 981 - 1050 GTKTAEMEEEASGKFGTVSSRDSQHLSTFNLERTAFRKDSQRWYVATEGGMAEKSGLEAATGKTFPRASG 1051 - 1120 LGAREAEGKEEGAPDGETSDGSGLGQGDRFLTDVTCASSAKDLDNPEDADSSTCDHPSKLPEADESVARL 1121 - 1190 CDYHLAKRMSSLQSEGHFSLQSSQGSSVDAGCGTGSSGSACATPVESPLCPSLGKHLIPDASGKGVNYIP 1191 - 1260 SEERAPGLPNHGATFKELHPQTEGMCPRMTVPALHTAINTEPLFGTLRDGCHRLPKIKETTV 1261 - 1322 //
