Tbio FRMD4B FERM domain-containing protein 4B

Protein Summary

Description

Member of GRP1 signaling complexes that are acutely recruited to plasma membrane ruffles in response to insulin receptor signaling. May function as a scaffolding protein that regulates epithelial cell polarity by connecting ARF6 activation with the PAR3 complex. Plays a redundant role with FRMD4A in epithelial polarization. This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. [provided by RefSeq, Mar 2014]

Uniprot Accession IDs

• Q9Y2L6
• Q8TAI3

Gene Name

• FRMD4B

Ensembl ID

• ENST00000398540
• ENSP00000381549
• ENSG00000114541

Symbol

• GRSP1
• KIAA1013
• GRSP1
• 6030440G05Rik

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
transcription factor perturbation	0.88
PubMedID	0.86
drug perturbation	0.71
transcription factor	0.69

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.71   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 40   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.71   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 40   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0