FRMD3
FERM domain-containing protein 3
Protein Summary
Putative tumor suppressor gene that may be implicated in the origin and progression of lung cancer. The protein encoded by this gene is a single pass membrane protein primarily found in ovaries. A similar protein in erythrocytes helps determine the shape of red blood cells, but the function of the encoded protein has not been determined. There is some evidence that this is a tumor suppressor gene, and there is also evidence linking defects in this gene to susceptibility to diabetic nephropathy in type 1 diabetes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
- ENST00000304195
- ENSP00000303508
- ENSG00000172159
- ENST00000328788
- ENSP00000328615
- ENST00000376434
- ENSP00000365617
- ENST00000376438
- ENSP00000365621
- ENST00000621208
- ENSP00000484839
- EPB41L4O
- 4.1O
- P410
- EPB41LO
- EPB41L4O
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
gene perturbation | 0.83 | ||
histone modification site profile | 0.78 | ||
phenotype | 0.65 | ||
PubMedID | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.54 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 127 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 34.54 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 127 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0