Tchem FPR3 N-formyl peptide receptor 3

Protein Summary

Description

Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophils chemotactic factors. Binding of FMLP to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system.

Uniprot Accession IDs

• P25089

Gene Name

• FPR3

Ensembl ID

• ENST00000339223
• ENSP00000341821
• ENSG00000187474
• ENST00000595991
• ENSP00000470471

Symbol

• FPRH1
• FPRL2
• FMLPY
• FPRH1
• FPRH2
• FPRL2
• RMLP-R-I
• FMLP-R-II
• FML2_HUMAN

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.97
hub protein	0.79
tissue sample	0.68
protein domain	0.58
gene perturbation	0.51

Protein Classes

PANTHER Classes

Protein / Receptor / G-protein Coupled Receptor / N-formyl Peptide Receptor 3

DTO Classes

Protein / G-protein Coupled Receptor / Class A Rhodopsin Like / Formyl Peptide Receptor / N-formyl Peptide Receptor 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.34   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 330   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.34   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 330   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0