FPR2
N-formyl peptide receptor 2
Protein Summary
Low affinity receptor for N-formyl-methionyl peptides, which are powerful neutrophil chemotactic factors (PubMed:1374236). Binding of FMLP to the receptor causes activation of neutrophils (PubMed:1374236). This response is mediated via a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:1374236). The activation of LXA4R could result in an anti-inflammatory outcome counteracting the actions of proinflammatory signals such as LTB4 (leukotriene B4) (PubMed:9547339). Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation (By similarity).
- ENST00000340023
- ENSP00000340191
- ENSG00000171049
- ENST00000598776
- ENSP00000468897
- ENST00000598953
- ENSP00000468876
- FPRH1
- FPRL1
- LXA4R
- ALXR
- HM63
- FMLPX
- FPR2A
- FPRH1
- FPRH2
- FPRL1
- LXA4R
- FMLP-R-II
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
ligand (protein) | 0.95 | ||
ligand (chemical) | 0.94 | ||
gene perturbation | 0.76 | ||
microRNA | 0.76 | ||
phenotype | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 561.02 (req: < 5)
Gene RIFs: 138 (req: <= 3)
Antibodies: 373 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 561.02 (req: >= 5)
Gene RIFs: 138 (req: > 3)
Antibodies: 373 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 24
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 347
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0