Property Summary

NCBI Gene PubMed Count 22
PubMed Score 52.80
PubTator Score 53.24

Knowledge Summary


No data available


  Disease (2)

Disease Target Count P-value
osteosarcoma 7933 2.6e-06
lung cancer 4473 5.3e-05
Disease Target Count Z-score Confidence
Transient cerebral ischemia 14 3.032 1.5


  Differential Expression (2)

Disease log2 FC p
osteosarcoma -1.576 2.6e-06
lung cancer -1.900 5.3e-05

Gene RIF (11)

25873280 Data shows that FOXJ2 is downregulated in extrahepatic cholangiocarcinoma tissues and associates with disease progression. Its overexpression inhibits cell proliferation, migration and invasion in vitro indicating a role as tumor suppressor gene.
25661068 FoxJ2 suppressed cell migration and invasion in glioma
25451482 Our analysis showed significant downregulation of miRNAs, let-7b and miR-197, out of which miR-197 was predicted to target FOXJ2.
24792364 MicroRNA-34a targets FOXJ2 to modulate differentiation of endothelial progenitor cells in response to shear stress.
22441887 Study demonstrates that FOXJ2 can inhibit the metastasis of human breast cancer by regulating the EMT key markers E-cadherin and vimentin.
20438785 Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator)
20406964 Observational study of gene-disease association. (HuGE Navigator)
20237496 Observational study of gene-disease association. (HuGE Navigator)
19423540 Observational study of gene-disease association. (HuGE Navigator)
18854154 Knockdown of forkhead box J2 (FOXJ2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1
18564921 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

NEEIPDDFDWDLIT                                                            561 - 574

Text Mined References (30)

PMID Year Title
25873280 2015 Abnormal expression of Forkhead Box J2 (FOXJ2) suppresses migration and invasion in extrahepatic cholangiocarcinoma and is associated with prognosis.
25661068 2015 The role of FoxJ2 in the migration of human glioma cells.
25609649 2015 Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes.
25451482 2015 STAT6 silencing up-regulates cholesterol synthesis via miR-197/FOXJ2 axis and induces ER stress-mediated apoptosis in lung cancer cells.
25416956 2014 A proteome-scale map of the human interactome network.
24792364 2014 MicroRNA-34a targets Forkhead box j2 to modulate differentiation of endothelial progenitor cells in response to shear stress.
24275569 2014 An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
22441887 2012 Overexpression of forkhead box J2 can decrease the migration of breast cancer cells.
20438785 2010 Polymorphisms in innate immunity genes and risk of childhood leukemia.
20406964 2010 Risk of meningioma and common variation in genes related to innate immunity.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
19690332 2009 Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.
19423540 2009 Common variation in genes related to innate immunity and risk of adult glioma.
19413330 2009 Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18564921 2008 Candidate gene analysis in primary lymphedema.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17974005 2007 The full-ORF clone resource of the German cDNA Consortium.
17525332 2007 ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12787665 2003 Functional domains of FOXJ2.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10966786 2000 FHX.L and FHX.S, two isoforms of the human fork-head factor FHX (FOXJ2) with differential activity.
10777590 2000 FHX, a novel fork head factor with a dual DNA binding specificity.
9110174 1997 Large-scale concatenation cDNA sequencing.
8889548 1996 Normalization and subtraction: two approaches to facilitate gene discovery.
8619474 1996 A "double adaptor" method for improved shotgun library construction.